1450

January–December

• February 7 - John de la Pole, 2nd Duke of Suffolk, marries Lady Margaret Beaufort.
• February 26 - Francesco Sforza enters Milan after a siege, becoming Duke of the city-state, and founding a dynasty that will rule Milan for a century.
• March - French troops under Guy de Richemont besiege the English commander in France, Edmund Beaufort, 1st Duke of Somerset, in Caen.
• April 15 - Battle of Formigny: French troops under the Comte de Clermont defeat an English army under Sir Thomas Kyriel and Sir Matthew Gough, which was attempting to relieve Caen.
• May 8 - Jack Cade's Rebellion: Kentishmen revolt against King Henry VI of England.
• May 9 - Abdal-Latif Mirza, a Timurid Dynasty monarch, is assassinated.
• May 13 - Charles VIII of Sweden, also serving as Carl I of Norway, is declared deposed from the latter throne, in favor of Christian I of Denmark.
• June 18 - Battle of Seven Oaks: Jack Cade's rebels are driven from London by loyal troops, bringing about the collapse of the rebellion.
• July 6 - Caen surrenders to the French.
• July 12 - Jack Cade is slain in a skirmish.
• August 12 - Cherbourg, the last English territory in Normandy, surrenders to the French.
• October 5 - Jews are expelled from Lower Bavaria, by order of Duke Ludwig IX.
• November 3 - The University of Barcelona is founded.
• November 23 - First Siege of Krujë: Albanian troops are victorious, forcing an Ottoman army of approximately 100,000 men to retreat from Albania.

  Date unknown

• Machu Picchu, a pre-Columbian Inca site located 2,400 meters above sea level, is believed to be under construction.
• A religious sacrifice of over a hundred children is performed around this time, outside of the ancient city of Chan Chan, on the north coast of Peru.
• Johannes Gutenberg has set up his movable type printing press, as a commercial operation in Mainz, by this date.

  Births

• February 12 - Yejong of Joseon, Joseon King
• May 18 - Piero Soderini, Florentine statesman
• June 22 - Eleanor of Naples, Duchess of Ferrara
• July 25 - Jakob Wimpfeling, Renaissance humanist
• August 18 - Marko Marulić, Croatian poet
• September 25 - Ursula of Brandenburg, Duchess of Münsterberg-Oels and Countess of Glatz
• November 12 - Jacques of Savoy, Count of Romont, Prince of Savoy
• date unknown
• * William Catesby, English politician
• * Bartolomeo Montagna, Italian painter
• * Heinrich Isaak, German-Dutch composer
• * John Cabot, English explorer
• probable
• * Kamāl ud-Dīn Behzād, Persian leader of the Herat school
• * Hieronymus Bosch, Dutch painter
• * Gaspar Corte-Real, Portuguese explorer
• * Juan de la Cosa, Spanish navigator and cartographer
• * Josquin des Prez, Dutch composer
• * Heinrich Isaac, Franco-Flemish composer
• * Hugh Oldham, Bishop of Exeter
• * Pietro Antonio Solari, Italian architect
• * Petrus Thaborita, Dutch historian and monk

  Deaths

• January 9 - Adam Moleyns, English courtier and Bishop of Chichester
• February 9 - Agnès Sorel, mistress of Charles VII of France
• April 8 - Sejong the Great of Joseon, ruler of Korea
• May 2 - William de la Pole, 1st Duke of Suffolk, English military leader
• May 9 - Abdal-Latif Mirza, ruler of Transoxania
• July 2 - Ranuccio Farnese il Vecchio, Italian condottiero
• July 4 - James Fiennes, 1st Baron Saye and Sele, English soldier and politician
• July 18 - Francis I, Duke of Brittany
• July 26 - Cecily Neville, Duchess of Warwick
• August 15 - Alberto da Sarteano, Italian Franciscan friar and papal legate
• August 27 - Reginald West, 6th Baron De La Warr, English politician
• August 31 - Isabella of Navarre, Countess of Armagnac
• September 16 - Louis Aleman, French cardinal
• September 22 - William Tresham, English politician
• October 1 - Leonello d'Este, Marquis of Ferrara, Italian noble
• November 3 - Paola Colonna, Lady of Piombino
• November 5 - John IV, Count of Armagnac