PA 350 begins at an intersection with PA 45 in the community of Seven Stars in Franklin Township, Huntingdon County, heading northwest on two-lane undivided Warriors Mark Path Road concurrent with PA 45 Truck. The road heads through open agricultural areas, passing through Graziers Mill. The route continues into Warriors Mark Township and runs through more farmland with occasional woods and homes, coming to the residential community of Warriors Mark. Here, PA 350 intersects PA 550, with PA 45 Truck turning southwest to follow PA 550. The route continues through more agricultural areas before coming to the community of Spring Mount, where it turns west to ascend forested Bald Eagle Mountain. At the summit of the mountain, PA 350 enters Snyder Township in Blair County and becomes Seven Stars Road, descending the mountain. The road passes under Interstate 99 and U.S. Route 220 and comes to a bridge over a Nittany and Bald Eagle Railroad line before passing a few farm fields and coming to a ramp that provides access to I-99/US 220. At this point, the route turns north onto an unnamed four-lane divided highway, passing through woods and coming to an intersection with US 220Business in the community of Bald Eagle. PA 350 passes through wooded areas with some homes from this point. PA 350 heads into Taylor Township in Centre County and becomes Old Tyrone Pike, turning northwest and running through more forests. The road enters Rush Township and turns to the north as South Centre Street, heading north through more rural areas and passing through Summit. The route heads north through forests with occasional development for several miles. PA 350 heads into a mix of fields and woods with some residences, becoming the border between Rush Township to the west and the borough of Philipsburg to the east. The road turns northwest into residential areas and fully enters Philipsburg. PA 350 splits into a one-way pair as it comes to the square in the center of town, ending at PA 53 and PA 504. Past the square, the road continues north as part of PA 53.
