Y-DNA haplogroups in indigenous peoples of the Americas
Listed here are notable Indigenous peoples of the Americas by human Y-chromosome DNA haplogroups based on relevant studies. The samples are taken from individuals identified with the ethnic and linguistic designations in the first two columns, the fourth column is the sample size studied, and the other columns give the percentage of the particular haplogroup.
| Group | Language | Place | n | C | Q | R1 | Others | Reference |
| Algonquian | Algic | Northeast North America | 155 | 7.7 | 33.5 | 38.1 | 20.6 | Bolnick 2006 |
| Apache | Na-Dené | SW United States | 96 | 14.6 | 78.1 | 5.2 | 2.1 | Zegura 2004 |
| Athabaskan | Na-Dené | Western North America | 243 | 11.5 | 70.4 | 18.1 | | Malhi 2008 |
| Cherokee | Macro-Siouan | SE United States | 62 | 1.6 | 50.0 | 37.1 | 11.3 | Bolnick 2006 |
| Cherokee | Iroquoian | Eastern North America | 30 | | 50.0 | 46.7 | 3.3 | Malhi 2008 |
| Cheyenne | Algic | United States | 44 | 16 | 61 | 16 | 7 | Zegura 2004 |
| Chibchan | Macro-Chibchan | Panama | 26 | | 100 | | | Zegura 2004 |
| Chipewyan | Na-Dené | Canada | 48 | 6 | 31 | | P1 62.5%. | Bortoloni 2003 |
| Chippewa | Algic | Eastern North America | 97 | 4.1 | 15.9 | 50.5 | 29.9 | Bolnick 2006 |
| Dogrib | Na-Dené | Canada | 15 | 33 | 27 | 40 | | Malhi 2008 |
| Dogrib | Na-Dené | Canada | 37 | 35.1 | 45.9 | 8.1 | 10.8 | Dulik 2012 |
Gê | Macro-Jê | Brazil | 51 | | 92 | 8 | | Bortoloni 2003 |
| Guaraní | Tupian | Paraguay | 59 | | 86 | 9 | 5 | Bortoloni 2003 |
| Inga | Quechua | Colombia | 11 | | 78 | 11 | 11 | Bortoloni 2003 |
| Inuit | Eskimo–Aleut | North American Arctic | 60 | | 80.0 | 11.7 | 8.3 | Zegura 2004 |
| Inuvialuit | Eskimo–Aleut | Canada | 56 | 1.8 | 55.1 | 33.9 | 8.9 | Dulik 2012 |
Maya | Mayan | Mesoamerica | 71 | | 87.3 | 12.7 | | Zegura 2004 |
| Mixe | Mixe–Zoque | Mexico | 12 | | 100 | | | Zegura 2004 |
| Mixtec | Oto-Manguean | Mexico | 28 | | 93 | 7 | | Zegura 2004 |
| Muskogean | Muskogean | SE United States | 36 | 2.8 | 75 | 11.1 | 11.1 | Bolnick 2006 |
| Nahua | Uto-Aztecan | Mexico | 17 | | 94 | | 6 | Malhi 2008 |
| Native Americans | | United States | 398 | 9.0 | 58.1 | 22.2 | 10.7 | Hammer 2005 |
| Navajo | Na-Dené | SW United States | 78 | 1.3 | 92.3 | 2.6 | 3.8 | Zegura 2004 |
| Native North Americans | | North America | 530 | 6.0 | 77.2 | 12.5 | 4.3 | Zegura 2004 |
| Papago | Uto-Aztecan | SE United States | 13 | | 61.5 | 38.5 | | Malhi 2008 |
| Seminole | Muskogean | Eastern North America | 20 | | 45.0 | 50.0 | 5.0 | Malhi 2008 |
| Sioux | Macro-Siouan | Central North America | 44 | 11 | 25 | 50 | 14 | Zegura 2004 |
| South America | Amerindian | South America | 390 | | 92 | 4 | 4 | Bortoloni 2003 |
| Tanana | Na-Dené | Northwest North America | 12 | 42 | 42 | 8 | 8 | Zegura 2004 |
| Ticuna | Ticuna–Yuri | West Amazon basin | 33 | | 100 | | | Bortoloni 2003 |
| Tlingit | Na-Dené | Pacific Northwest | 11 | 18 | 82 | | | Dulik 2012 |
| Tupí–Guaraní | Tupian | Brazil | 54 | | 100 | | | Bortoloni 2003 |
| Uto-Aztecan | Uto-Aztecan | Mexico, Arizona | 167 | | 93.4 | 6.0 | | Malhi 2008 |
| Warao | Warao | Caribbean South America | 12 | | 100 | | | Bortoloni 2003 |
| Wayúu | Arawakan | Guajira Peninsula | 19 | | 69 | 21 | 10 | Bortoloni 2003 |
| Wayúu | Arawakan | Guajira Peninsula | 25 | 8 | 36 | 44 | 12 | Zegura 2004 |
| Yagua | Peba–Yaguan | Peru | 7 | | 100 | | | Bortoloni 2003 |
| Yukpa | Cariban | Colombia | 12 | | 100 | | | Bortoloni 2003 |
| Zapotec | Oto-Manguean | Mexico | 16 | | 75 | 6 | 19 | Zegura 2004 |
| Zenú | extinct | Colombia | 30 | | 81 | | 19 | Bortoloni 2003 |
