Umespirone


Umespirone is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties. It behaves as a 5-HT1A receptor partial agonist, D2 receptor partial agonist, and α1-adrenoceptor receptor antagonist, and also has weak affinity for the sigma receptor. Unlike many other anxiolytics and antipsychotics, umespirone produces minimal sedation, cognitive/memory impairment, catalepsy, and extrapyramidal symptoms.