On July 3, 2014, Cumia was fired by SiriusXM after making a series of tweets, that they deemed racist, following an off-air incident with a black woman on the street. Cumia was punched by the woman while attempting to take pictures of Times Square. Cumia stated on the Saturday, July 12 episode of Red Eye w/Greg Gutfeld that he was not going to apologize for the incident. Cumia deleted the tweets after being fired. At the time of Cumia's firing SiriusXM made no comment as to Hughes' possible future with the company at that time. Cumia gave his blessing for the Sirius XM show to continue without him, acknowledging Hughes and Norton's obligation to fulfil their contract with SiriusXM. A relaunched Opie with Jim Norton resumed on July 14, 2014 with Hughes and Norton discussing the incident and noting that The Opie and Anthony Channel was renamed SiriusXM Talk, along with various other alterations by the company in light of the firing. In October 2014, Hughes and Norton signed a new contract to continue the SiriusXM show, which appeared on the rebranded, and now defunct, Opie Radio channel.
Launch and new studio
Cumia announced on July 8, 2014, that he would launch a new Internet-based podcast as The Anthony Cumia Show, which began airing in August 2014. This show was kept separate from his old internet radio show Live from the Compound, which Anthony had set up as a hobby, unrelated to his future show in the same studio. Cumia's website later specified that "his live, uncensored HD video podcast" called The Anthony Cumia Show would launch on August 4. Beginning in August 2014 the show aired exclusively from Cumia's basement studio where he hosted his previous show, Live from the Compound. In 2015, Cumia and his producers announced that they were looking into setting up a studio in New York City in order to secure more guests to appear on the program. Starting in August 2015, the show began broadcasting from a second studio in midtown Manhattan. Cumia stated that this new location would be the primary studio going forward, with some broadcasts from the original Long Island studio on special occasions. On March 30, 2016 Cumia announced that he would be spending the month of April in drug and alcohol rehab. He announced that while in rehab he would have a group of comedians and friends fill in for his show.
Cumia is the only host of the show but in January 2015, he stated he would be willing to have a co-host if it were the right person. During an appearance on Jim Norton and Sam Roberts on Sirius XM in July 2017, it was stated that a co-host for the show had been found and will be announced in the following month. On August 21, 2017, Cumia revealed comedian and actor Artie Lange as the co-host of The Artie and Anthony Show. It launched on September 5, 2017, airing Monday to Thursday, from 4–6 p.m. In May 2018, it was announced that due to his health and legal issues, Lange would be taking an indefinite hiatus from the show, and it would revert to the name The Anthony Cumia Show, with third mic Dave Landau continuing as co-host.