Prior to the opening of the school in the late summer of 1962, students in what is now known as the Seminole area attended Largo High School or Dixie Hollins High School. With rapid growth in Seminole in the late 1950s and early 1960s, it became necessary for the newly suburban area to have its own high school. The original school consisted of what is now the main building where the administration offices are located and the front cafeteria. Seminole was the first high school in Pinellas County to be air-conditioned. The current "Warhawk" stadium was built in 1967 after a lengthy fundraising drive. The auditorium, gymnasium and band facilities were built in later years. The school underwent a significant expansion in 1977 and an extensive remodeling in 1996. In the fall of 1973, the school utilized double sessions until the opening of Osceola High School in 1981.
Athletics
Seminole High School athletic programs include baseball, basketball, ten pin bowling, cheerleading, cross country, flag football, football, golf, soccer, softball, spring football, swimming, diving, tennis, track, volleyball, and wrestling.
Soccer
During 2003 season, the Seminole soccer team won the state championship.
Baseball
The Seminole Warhawk baseball team won the state title in 2001.
In 2006 The Seminole High School Orchestra played at Carnegie Hall. The Orchestra also played for the governor, and at the invitation-only event for Disney Honors.
Vocal
SHS has three auditioned choirs and two non-auditioned choruses.
Marching Band
The Seminole High School Warhawk Marching Band has won the FMBC Florida State Class 4A Championships in 2018, 2012, 2011, 2006, and more. They were the grand champions at the 2017 USBands Southern States Regional Championship in Chattanooga, TN. They were the grand champions of the Virginia Beach National Marching Band Festival. They have also marched in parades, including Tournament of Roses Parade in Pasadena, CA, Disney Christmas Day Parade, Macy's Thanksgiving Day Parade.
Concert Bands
The Wind Ensemble is the top level concert band. Membership is by audition. The Symphonic Band is the intermediate level concert band of the program, and is composed of students that have the ability to perform music at grade 3 or higher. It is open to any Seminole students who are interested.
Jazz Bands
The "All In" Big Band is the top jazz band at Seminole High, and has received superior ratings at State MPAs for multiple consecutive years. The "High Noon" Jazz Ensemble is the second jazz band, and is open to any students interested.
Drama and Musical Theatre Department
The Seminole High School Drama and Musical Theatre Department, also known as Troupe 3039 at competitions, usually put on at least one musical a year, and compete at the Florida Thespians District and State competitions every year.
