Saccharopine dehydrogenase (NADP+, L-glutamate-forming)
In enzymology, a saccharopine dehydrogenase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are N6--L-lysine, NADP+, and H2O, whereas its 4 products are L-glutamate, L-2-aminoadipate 6-semialdehyde, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N6--L-lysine:NADP+ oxidoreductase . Other names in common use include saccharopine dehydrogenase, aminoadipic semialdehyde-glutamic reductase, aminoadipate semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamate reductase, epsilon-N--L-lysine:NAD+ oxidoreductase, ', saccharopine reductase, 6-N--L-lysine:NADP+ oxidoreductase, and '. This enzyme participates in lysine biosynthesis and lysine degradation.As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and.
