After graduating from high school, Wendell attended Fresno State University, where he started in 9 games as a true freshman in 2004 and earned WAC Co-Freshman of the Year. He started all 13 games of his sophomore season and all 12 games of his junior season, earning All-WAC honors. As a senior he started at center.
Wendell was signed by the Patriots as an undrafted free agent on May 1, 2008. He was waived by the team on August 26, 2008, and signed to the Patriots' practice squad on September 24, 2008. He spent the remainder of the season on the practice squad and was re-signed to a future contract following the season. The Patriots waived Wendell on September 22, 2009. He was re-signed to the team's practice squad two days later. In mid-season, the Patriots raised Wendell's salary in mid-season from the practice-squad minimum to that of a first-year active-roster player. Wendell was promoted to the active roster on December 31, 2009. Wendell played in 15 games for the Patriots in the 2010 season. He started the final two games of the season in place of an injured Dan Connolly. During training camp before the 2012 season, Wendell was part of a competition for the starting center job in New England. He beat out longtime Patriot Dan Koppen for the job. In 2012, counting special teams, he played a total of 1,379 snaps, the most of any NFL player. As a result, he earned a bonus of $179,907 from the Patriots in March 2013 as a result of the NFL's "performance-based pay" system, which rewards players who have high playing time and low salaries. On March 28, 2014, Wendell signed a two-year deal worth up to $3.25 million. During the week five 2014 Sunday Night Football game against the Bengals, Wendell was moved to guard, where he enjoyed immediate success on a Patriots team experimenting with their offensive line. The offensive line only allowed one sack the entire game. Wendell started the rest of the year at right guard, and was a part of the offensive line that won Super Bowl XLIX 28–24 over the Seattle Seahawks. Prior to the 2015 season, Wendell was voted a captain by his teammates for the first time in his career. He missed the first five games of the 2015 season with an illness and played a reserve role the next two games before being placed on injured reserve on November 7, 2015, ending his time with the Patriots.
