Seals-Jones played college football for Texas A&M from 2013 to 2016 under head coach Kevin Sumlin.
2013 season
As a true freshman, he ended up redshirting after only appearing in two games before suffering a season-ending injury. In the game against Rice, he had his first three collegiate receptions for 84 yards, which included a 71-yard touchdown reception from quarterback Matt Joeckel.
2014 season
As a redshirt freshman, his role in the offense expanded. In the season opener against #9 South Carolina, he recorded five receptions for 67 yards and a touchdown. In the next two games, against Lamar and Rice, he recorded a receiving touchdown in both games. On October 4, in a 48–31 loss against SEC West rival #12 Mississippi State, he had a season-high 10 receptions for 72 yards. He finished his redshirt freshman season with a single reception for 21 yards against West Virginia in the 45–37 victory in the 2014 Liberty Bowl.
2015 season
As a redshirt sophomore, he played in all 13 games. On October 3, he scored his first receiving touchdown of the season against #21 Mississippi State. On October 17, he had his best collegiate performance against #10 Alabama with six receptions for 107 yards and a touchdown. He finished out the season with three receptions for 18 yards and a touchdown in the 27–21 defeat to Louisville in the 2015 Music City Bowl.
2016 season
As a redshirt junior, his production dropped but still was an important contributor to the Aggies. On September 3, against #16 UCLA in the season opener, he had four receptions for 57 yards in the 31–24 victory. On September 24, against #17 Arkansas, he recorded one reception for 47 yards before suffering a left leg injury. He returned from his injury to play against #1 Alabama over a month later, but only had a single reception for 25 yards in the 33–14 loss. On November 19, against UTSA, he had six receptions for a season-high 75 yards. In his final game with the Aggies, he had six receptions for 34 yards and his lone touchdown of the 2016 season in the 33–28 loss to the Kansas State Wildcats in the 2016 Texas Bowl. After the 2016 season, he decided to enter the 2017 NFL Draft.
Collegiate statistics
Professional career
Arizona Cardinals
Seals-Jones was signed by the Arizona Cardinals as an undrafted free agent on May 2, 2017. He was waived on September 2, 2017 and was signed to the practice squad the next day. He was promoted to the active roster on September 25, 2017. On September 25, 2017, in Week 3 against the Dallas Cowboys, he appeared on special teams in his NFL debut. In Week 11, against the Houston Texans, he had recorded three receptions for 54 yards and the first two touchdowns of his professional career. He followed that up with four receptions for 72 yards and a touchdown in the next game against the Jacksonville Jaguars. He finished the season with 12 receptions for 201 yards and three touchdowns in 10 games and one start. In 2018, Seals-Jones played in 15 games with five starts, recording 34 receptions for 343 yards and one touchdown. Prior to the 2019 season, he was waived by the Cardinals during final roster cuts on August 31, 2019.
On September 1, 2019, Seals-Jones was claimed off waivers by the Cleveland Browns. In week 15 against his former team, the Arizona Cardinals, Seals-Jones caught 3 passes for 29 yards and 2 touchdowns during the 38–24 loss.
Kansas City Chiefs
On April 9, 2020, the Kansas City Chiefs signed Seals-Jones to a one-year contract.
