Pyrroline-5-carboxylate reductase
In enzymology, a pyrroline-5-carboxylate reductase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD+ 5-oxidoreductase. Other names in common use include proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and L-proline-NAD+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and.Human genes
