Methylphenylpiracetam


Methylphenylpiracetam is a derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. It differs from phenylpiracetam by having a methyl group.
E1R is the stereoisomer of methylphenylpiracetam.

Enantiomers

The two R-configuration enantiomers, i.e. and, of methylphenylpiracetam are more active positive allosteric modulators of the sigma-1 receptor than the two S-configuration enantiomers, i.e. and.
Enantiomerσ1R PAM effect %
erythro-222 ± 37
threo-191 ± 23
erythro-141 ± 40
threo-147 ± 31

Effects

E1R enhances cognition and has efficacy against cholinergic dysfunction in mice without affecting locomotor activity. Pretreatment with E1R enhanced the σ1R agonist PRE-084's stimulating effect and facilitated passive avoidance retention. It alleviated scopolamine-induced cognitive impairment. The cognition enhancing activity of E1R is higher than that of -phenylpiracetam.
Because E1R had no effect on locomotor activity, it was found to be free of potential motor side effects.

Legality

Australia

Methylphenylpiracetam is a schedule 4 substance in Australia under the Poisons Standard. A schedule 4 substance is classified as "Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription."