Methylenetetrahydrofolate dehydrogenase (NAD+)


In enzymology, a methylenetetrahydrofolate dehydrogenase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NAD+, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase. This enzyme is also called methylenetetrahydrofolate dehydrogenase . This enzyme participates in one carbon pool by folate.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.