After graduation, Zlotowitz, who as a youth used his talent in art to overcome his stuttering, became director of a high-end graphics studio in New York. The firm, named ArtScroll Studios, produced brochures, invitations, awards and ketubahs. Rabbi Nosson Scherman, then principal of Yeshiva Karlin StolinBoro Park, was recommended to Zlotowitz as someone who could write copy, and they collaborated on a few projects. In late 1975, he wrote an English translation and commentary on the Book of Esther in memory of a young married friend, a rebbe in Yeshiva Torah Emes who died childless, and asked Scherman to write the introduction. The manuscript was completed in honor of the shloshim and "was published in February 1976, just in time to market it for Purim that year." Its first edition of 20,000 copies sold out within two months. With the encouragement of Rabbi Moses Feinstein, Rabbi Yaakov Kamenetsky and other Gedolei Yisrael, the two continued producing commentaries, beginning with a translation and commentary on the rest of the Five Megillot, and went on to publish translations and commentaries on the Torah, Prophets, Talmud, Passover Haggadah, siddurs and machzors. By 1990 ArtScroll had produced more than 700 books, including novels, history books, children's books and secular textbooks, and became one of the largest publishers of Jewish books in the United States. Zlotowitz was also chairman of the Mesorah Heritage Foundation, ArtScroll's fundraising arm. Zlotowitz died in Brooklyn on 24 June 2017 at the age of 73. By the end of the year of mourning for a parent, Meir's son [|Gedaliah] was listed in newly released ArtScroll publications, secondarily alongside that of his late father's partner, Nosson Scherman, as general editor.
Until the death of Meir, Zlotowitz and Scherman were the general editors of ArtScroll's Talmud, Chumash, Tanakh, Siddur and Machzor series. They co-authored Megillas Esther: Illustrated Youth Edition, a pocket-size Mincha/Maariv prayerbook, and Selichos: First Night. They have also produced a host of titles of which Scherman is author and Zlotowitz is editor. Newly released publications list Scherman first, followed by Gedaliah Zlotowitz as general editors. Zlotowitz is the author of:
Esther: The Megillah: A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1976
Eichah : A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1976
Koheles : A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1976
Ruth: A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1976
Shir HaShirim : A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1976
Yonah : A new translation with a commentary anthologized from Talmudic, Midrashic and Rabbinic sources, 1978
Chanukah: Its history, observance and significance, 1981
Succos: Its significance, laws and prayers: A presentation anthologized from Talmudic and Midrashic sources, 1982
Shema Yisrael: A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1982
Pirkei Avos, 1984
Bereishis: A new translation with a commentary anthologized from Talmudic, Midrashic, and rabbinic sources, 1986
A biography, authored by Rabbi Yisroel Besser, was written by the time of the first Yartzeit.
Gedaliah Zlotowitz
Rabbi Gedaliah Zlotowitz, was Rabbi Meir's oldest son. Arscroll's Titles by Rabbi Gedaliah Zlotowitz had nine entries as of early 2019.