Leblanc was born in Rouen, Normandy, where he was educated at Lycée Pierre-Corneille. After studying in several countries and dropping out of law school, he settled in Paris and began to write fiction, both short crime stories and longer novels. The latter, heavily influenced by writers like Gustave Flaubert and Guy de Maupassant, were critically admired but had little commercial success. Leblanc was largely considered little more than a writer of short stories for various French periodicals until the first Arsène Lupin story appeared in a series of short stories that was serialized in the magazineJe sais tout, starting in No. 6, dated 15 July 1905. Clearly created at editorial request under the influence of and in reaction to the wildly successful Sherlock Holmes stories, the roguish and glamorous Lupin was a surprise success and Leblanc's fame and fortune beckoned. In total, Leblanc went on to write 21 Lupin novels or collections of short stories. The character of Lupin might have been based by Leblanc on French anarchistMarius Jacob, whose trial made headlines in March 1905. It is also possible that Leblanc had also read Octave Mirbeau's Les 21 jours d'un neurasthénique, which features a gentleman thief named Arthur Lebeau, and he had seen Mirbeau's comedy Scrupules, whose main character is a gentleman thief. , today the museum Le clos Arsène Lupin. By 1907, Leblanc had graduated to writing full-length Lupin novels, and the reviews and sales were so good that Leblanc effectively dedicated the rest of his career to working on the Lupin stories. Like Conan Doyle, who often appeared embarrassed or hindered by the success of Sherlock Holmes and seemed to regard his success in the field of crime fiction as a detraction from his more "respectable" literary ambitions, Leblanc also appeared to have resented Lupin's success. Several times, he tried to create other characters, such as private eyeJim Barnett, but he eventually merged them with Lupin. He continued to pen Lupin tales well into the 1930s. Leblanc also wrote two notable science fiction novels: Les Trois Yeux, in which a scientist makes televisual contact with three-eyed Venusians, and Le Formidable Evènement, in which an earthquake creates a new landmass between England and France. Leblanc was awarded the Légion d'Honneur for his services to literature, and died in Perpignan in 1941. He was buried in the Montparnasse Cemetery. Georgette Leblanc was his sister.
The character Arsène Lupin III, protagonist of the Japanese mangaLupin III beginning in 1967, was written as the grandson of Arsène Lupin but without permission from Leblanc's estate. That was later the source of a lawsuit though the copyright on Leblanc's work has since expired. When the anime version was broadcast in France, the character was renamed Edgar, le détective cambrioleur. The authors of the various Lupin III properties drew on Leblanc's novels as inspiration; notably, the film The Castle of Cagliostro was loosely based on La Comtesse de Cagliostro. He is also referenced in Persona 5 where the main character's persona is the character Arsène. The main character is staying at Cafe Leblanc after being expelled from his former school for defending a woman.