Route 22 commenced operation on 17 May 1909 between Clapton and Elephant & Castle via Clapton, Hackney, Dalston, Shoreditch, London Bridge and Borough. On 26 July 1909 it was extended to Leyton with a Sunday extension to Epping Forest via Whipps Cross and Woodford replacing route 9. On 28 October 1909 route 22 was changed again to work between Tulse Hill and Leyton via Effra Road, Brixton Road, Kennington Park Road, Elephant & Castle and Whipps Cross. On 3 January 1910, it was cut back again to work Clapton to Tulse Hill. From 6 April 1911, route 22 was withdrawn between Bank and Elephant & Castle, being replaced by new route 35 over that section. At the same time it was extended to Putney station via Cheapside, Holborn, Piccadilly, Kings Road and Putney Bridge. The daily extension to Homerton commenced soon after on 12 June 1911, but the route was withdrawn throughout on Sundays on 8 October 1911 for just over three years until 8 November 1914, when it became daily once again. The connection with route 35 became clear once again as from 6 August 1916, when route 22 was diverted daily at Putney Bridge to run to Putney Common, but withdrawn on Sundays between Lower Clapton and Homerton being extended to Chingford via Leyton and Walthamstow, replacing route 35A on that day. This change was very short lived and route 22 reverted to being a daily Putney Common to Homerton route on 2 October 1916. On 1 December 1924, short-workings between Tottenham Court Road and Putney were numbered 22A, short-workings between Tottenham Court Road and Homerton were numbered 22B and short-workings between Piccadilly Circus and Homerton were numbered 22C. The plain 22 route number being used for journeys for the whole length of the route from Putney Common to Homerton. By 30 June 1925, these had been reduced to 22 Putney Common to Homerton and 22A Piccadilly Circus - Homerton. This situation remained until 3 October 1934, when the newly constituted London Passenger Transport Board instituted its own numbering system, which generally re-instated the situation previous to December 1924, in this case, leaving just the plain 22 to work Putney Common to Homerton. On 9 August 1939, RT1 buses were used to run the route from Homerton to Putney. Upon being re-tendered, London General commenced a new seven-year contract from 22 July 2000. On 22 July 2005 crewed operation finished with the AEC Routemasters replaced by Wright Eclipse Gemini bodied Volvo B7TLs. On 20 October 2012, London General commenced a new contract after successfully re-tendering to retain the route. On 15 July 2017, the route was withdrawn between Green Park station and Piccadilly Circus and diverted to Oxford Circus via Berkeley Square to replace route C2. On 21 October 2017, London General will commence a further contract. It is operated out of Putney garage with a peak vehicle requirement of 21.
