| City | Country / Region | IATA | ICAO | Airport | Notes | Refs |
| Ahmedabad | India | AMD | VAAH | Sardar Vallabhbhai Patel International Airport | Operated by Thai Smile | |
| Amsterdam | Netherlands | AMS | EHAM | Amsterdam Airport Schiphol | Terminated | |
| Auckland | New Zealand | AKL | NZAA | Auckland Airport | | |
| Athens | Greece | ATH | LGAV | Athens International Airport | Terminated | |
| Baghdad | Iraq | BGW | ORBI | Baghdad International Airport | Terminated | |
| Bandar Seri Begawan | Brunei | BWN | WBSB | Brunei International Airport | Terminated | |
| Bangkok | Thailand | DMK | VTBD | Don Mueang International Airport | Terminated | |
| Bangkok | Thailand | BKK | VTBS | Suvarnabhumi Airport | | |
| Barcelona | Spain | BCN | LEBL | Barcelona El-Prat Airport | Terminated | |
| Beijing | China | PEK | ZBAA | Beijing Capital International Airport | | |
| Bengaluru | India | BLR | VOBL | Kempegowda International Airport | | |
| Brisbane | Australia | BNE | YBBN | Brisbane Airport | | |
| Brussels | Belgium | BRU | EBBR | Brussels Airport | | |
| Buriram | Thailand | BFV | VTUO | Buriram Airport | Terminated | |
| Busan | South Korea | PUS | RKPK | Gimhae International Airport | Terminated | |
| Cairns | Australia | CNS | YBCS | Cairns Airport | Terminated | |
| Cairo | Egypt | CAI | HECA | Cairo International Airport | Terminated | |
| Changsha | China | CSX | ZGHA | Changsha Huanghua International Airport | Terminated | |
| Chengdu | China | CTU | ZUUU | Chengdu Shuangliu International Airport | Terminated | |
| Chennai | India | MAA | VOMM | Chennai International Airport | | |
| Chiang Mai | Thailand | CNX | VTCC | Chiang Mai International Airport | | |
| Chiang Rai | Thailand | CEI | VTCT | Chiang Rai International Airport | Operated by Thai Smile | |
| Chittagong | Bangladesh | CGP | VGEG | Shah Amanat International Airport | Terminated | |
| Chongqing | China | CKG | ZUCK | Chongqing Jiangbei International Airport | Terminated | |
| Christchurch | New Zealand | CHC | NZCH | Christchurch International Airport | Terminated | |
| Colombo | Sri Lanka | CMB | VCBI | Bandaranaike International Airport | | |
| Copenhagen | Denmark | CPH | EKCH | Copenhagen Airport | | |
| Dallas | United States | DFW | KDFW | Dallas/Fort Worth International Airport | Terminated | |
| Da Nang | Vietnam | DAD | VVDN | Da Nang International Airport | Terminated | |
| Denpasar | Indonesia | DPS | WADD | Ngurah Rai International Airport | | |
| Dhahran | Saudi Arabia | DHA | OEDR | Dhahran International Airport | Terminated | |
| Dhaka | Bangladesh | DAC | VGHS | Shahjalal International Airport | | |
| Dubai | United Arab Emirates | DXB | OMDB | Dubai International Airport | Terminated | |
| Düsseldorf | Germany | DUS | EDDL | Düsseldorf Airport | Terminated | |
| Frankfurt | Germany | FRA | EDDF | Frankfurt Airport | | |
| Fukuoka | Japan | FUK | RJFF | Fukuoka Airport | Terminated | |
| Gaya | India | GAY | VEGY | Gaya Airport | Operated by Thai Smile | |
| Geneva | Switzerland | GVA | LSGG | Geneva Airport | Terminated | |
| Guam | Guam | GUM | PGUM | Antonio B. Won Pat International Airport | Terminated | |
| Guangzhou | China | CAN | ZGGG | Guangzhou Baiyun International Airport | | |
| Hanoi | Vietnam | HAN | VVNB | Noi Bai International Airport | | |
| Hat Yai | Thailand | HDY | VTSS | Hat Yai International Airport | Operated by Thai Smile | |
| Helsinki | Finland | HEL | EFHK | Helsinki Airport | Terminated | |
| Ho Chi Minh City | Vietnam | SGN | VVTS | Tan Son Nhat International Airport | | |
| Hong Kong | Hong Kong | HKG | VHHH | Hong Kong International Airport | | |
| Hong Kong | Hong Kong | HKG | VHHH | Kai Tak Airport | Airport Closed | |
| Hyderabad | India | HYD | VOHS | Rajiv Gandhi International Airport | | |
| Islamabad | Pakistan | ISB | OPRN | Benazir Bhutto International Airport | Airport Closed | |
| Islamabad | Pakistan | ISB | OPIS | Islamabad International Airport | | |
| Jaipur | India | JAI | VIJP | Jaipur International Airport | Operated by Thai Smile | |
| Jakarta | Indonesia | CGK | WIII | Soekarno–Hatta International Airport | | |
| Jeddah | Saudi Arabia | JED | OEJN | King Abdulaziz International Airport | Hajj | |
| Jinghong | China | JHG | ZPJH | Xishuangbanna Gasa Airport | Terminated | |
| Johannesburg | South Africa | JNB | FAJS | O. R. Tambo International Airport | Terminated | |
| Kaohsiung | Taiwan | KHH | RCKH | Kaohsiung International Airport | Operated by Thai Smile | |
| Karachi | Pakistan | KHI | OPKC | Jinnah International Airport | Terminated | |
| Kathmandu | Nepal | KTM | VNKT | Tribhuvan International Airport | | |
| Khon Kaen | Thailand | KKC | VTUK | Khon Kaen Airport | Operated by Thai Smile | |
| Koh Samui | Thailand | USM | VTSM | Samui Airport | Terminated | |
| Kolkata | India | CCU | VECC | Netaji Subhas Chandra Bose International Airport | | |
| Kota Kinabalu | Malaysia | BKI | WBKK | Kota Kinabalu International Airport | Operated by Thai Smile | |
| Krabi | Thailand | KBV | VTSG | Krabi International Airport | | |
| Kuala Lumpur | Malaysia | KUL | WMKK | Kuala Lumpur International Airport | | |
| Kuala Lumpur | Malaysia | SZB | WMSA | Sultan Abdul Aziz Shah Airport | Terminated | |
| Kunming | China | KMG | ZPPP | Kunming Changshui International Airport | Terminated | |
| Kunming | China | KMG | ZPPP | Kunming Wujiaba International Airport | Airport Closed | |
| Kuwait City | Kuwait | KWI | OKBK | Kuwait International Airport | Terminated | |
| Lahore | Pakistan | LHE | OPLA | Allama Iqbal International Airport | | |
| Lampang | Thailand | LPT | VTCL | Lampang Airport | Terminated | |
| Langkawi | Malaysia | LGK | WMKL | Langkawi International Airport | Terminated | |
| Lashio | Myanmar | LSH | VYLS | Lashio Airport | Terminated | |
| Loei | Thailand | LOE | VTUL | Loei Airport | Terminated | |
| London | United Kingdom | LHR | EGLL | London Heathrow International Airport | | |
| Los Angeles | United States | LAX | KLAX | Los Angeles International Airport | Terminated | |
| Luang Prabang | Laos | LPQ | VLLB | Luang Prabang International Airport | Operated by Thai Smile | |
| Lucknow | India | LKO | VILK | Chaudhary Charan Singh International Airport | Operated by Thai Smile | |
| Macau | Macao | MFM | VMMC | Macau International Airport | Terminated | |
| Madrid | Spain | MAD | LEMD | Madrid-Barajas International Airport | Terminated | |
| Mae Hong Son | Thailand | HGN | VTCH | Mae Hong Son Airport | Terminated | |
| Mae Sot | Thailand | MAQ | VTPM | Mae Sot Airport | Terminated | |
| Manama | Bahrain | BAH | OBBI | Bahrain International Airport | Terminated | |
| Manila | Philippines | MNL | RPLL | Ninoy Aquino International Airport | | |
| Medina | Saudi Arabia | MED | OEMA | Prince Mohammad bin Abdulaziz International Airport | Hajj | |
| Melbourne | Australia | MEL | YMML | Melbourne Airport | | |
| Milan | Italy | MXP | LIMC | Milan–Malpensa Airport | | |
| Moscow | Russia | DME | UUDD | Domodedovo International Airport | Terminated | |
| Mumbai | India | BOM | VABB | Chhatrapati Shivaji Maharaj International Airport | | |
| Munich | Germany | MUC | EDDM | Munich Airport | | |
| Muscat | Oman | MCT | OOMS | Muscat International Airport | Terminated | |
| Nakhon Phanom | Thailand | KOP | VTUW | Nakhon Phanom Airport | Terminated | |
| Nakhon Ratchasima | Thailand | NAK | VTUQ | Nakhon Ratchasima Airport | Terminated | |
| Nakhon Si Thammarat | Thailand | NST | VTSF | Nakhon Si Thammarat Airport | Terminated | |
| Nagoya | Japan | NGO | RJGG | Chubu Centrair International Airport | | |
| New Delhi | India | DEL | VIDP | Indira Gandhi International Airport | | |
| Nan | Thailand | NNT | VTCN | Nan Airport | Terminated | |
| Narathiwat | Thailand | NAW | VTSC | Narathiwat Airport | Operated by Thai Smile | |
| New York City | United States | JFK | KJFK | John F. Kennedy International Airport | Terminated | |
| Nouméa | New Caledonia | NOU | NWWW | La Tontouta International Airport | Terminated | |
| Osaka | Japan | KIX | RJBB | Kansai International Airport | | |
| Oslo | Norway | OSL | ENGM | Oslo Gardermoen Airport | | |
| Paris | France | CDG | LFPG | Charles de Gaulle Airport | | |
| Pattani | Thailand | PAN | VTSK | Pattani Airport | Terminated | |
| Penang | Malaysia | PEN | WMKP | Penang International Airport | Operated by Thai Smile | |
| Perth | Australia | PER | YPPH | Perth Airport | | |
| Phetchabun | Thailand | PHY | VTPB | Phetchabun Airport | Terminated | |
| Phitsanulok | Thailand | PHS | VTPP | Phitsanulok Airport | Terminated | |
| Phnom Penh | Cambodia | PNH | VDPP | Phnom Penh International Airport | | |
| Phrae | Thailand | PRH | VTCP | Phrae Airport | Terminated | |
| Phuket | Thailand | HKT | VTSP | Phuket International Airport | | |
| Rome | Italy | FCO | LIRF | Leonardo da Vinci–Fiumicino International Airport | | |
| Riyadh | Saudi Arabia | RUH | OERK | King Khalid International Airport | Terminated | |
| Sakon Nakhon | Thailand | SNO | VTUI | Sakon Nakhon Airport | Terminated | |
| Sapporo | Japan | CTS | RJCC | New Chitose Airport | Terminated | |
| Seattle | United States | SEA | KSEA | Seattle–Tacoma International Airport | Terminated | |
| Sendai | Japan | SDJ | RJSS | Sendai Airport | Terminated | |
| Seoul | South Korea | ICN | RKSI | Incheon International Airport | | |
| Shanghai | China | PVG | ZSPD | Shanghai Pudong International Airport | | |
| Siem Reap | Cambodia | REP | VDSR | Siem Reap International Airport | Operated by Thai Smile | |
| Singapore | Singapore | QPG | WSAP | Paya Lebar Air Base | Airport Closed | |
| Singapore | Singapore | SIN | WSSS | Singapore Changi Airport | | |
| Stockholm | Sweden | ARN | ESSA | Stockholm Arlanda Airport | | |
| Surat Thani | Thailand | URT | VTSB | Surat Thani Airport | Operated by Thai Smile | |
| Sydney | Australia | SYD | YSSY | Sydney–Kingsford Smith International Airport | | |
| Taipei | Taiwan | TPE | RCTP | Taoyuan International Airport | | |
| Tak | Thailand | TKT | VTPT | Tak Airport | Terminated | |
| Tehran | Iran | THR | OIII | Tehran Mehrabad International Airport | Terminated | |
| Tehran | Iran | IKA | OIIE | Tehran Imam Khomeini International Airport | Terminated | |
| Tokyo | Japan | HND | RJTT | Haneda Airport | | |
| Tokyo | Japan | NRT | RJAA | Narita International Airport | | |
| Toronto | Canada | YYZ | CYYZ | Toronto Pearson International Airport | Terminated | |
| Trang | Thailand | TST | VTST | Trang Airport | Terminated | |
| Ubon Ratchathani | Thailand | UBP | VTUU | Ubon Ratchathani Airport | Operated by Thai Smile | |
| Udon Thani | Thailand | UTH | VTUD | Udon Thani Airport | Operated by Thai Smile | |
| Varanasi | India | VNS | VIBN | Lal Bahadur Shastri International Airport | Operated by Thai Smile
via Gaya | |
| Vienna | Austria | VIE | LOWW | Vienna International Airport | | |
| Vientiane | Laos | VTE | VLVT | Wattay International Airport | | |
| Xiamen | China | XMN | ZSAM | Xiamen Gaoqi International Airport | Terminated | |
| Yangon | Myanmar | RGN | VYYY | Yangon International Airport | | |
| Zhengzhou | China | CGO | ZHCC | Zhengzhou Xinzheng International Airport | Operated by Thai Smile | |
| Zürich | Switzerland | ZRH | LSZH | Zürich Airport | | |
| Country/Territory | City/Region | Airport | Notes | Ref |
| Chittagong | Shah Amanat International Airport | | |
| Phnom Penh | Phnom Penh International Airport | | |
| Siem Reap | Siem Reap International Airport | | |
| Changsha | Changsha Huanghua International Airport | | |
| Chongqing | Chongqing Jiangbei International Airport | | |
| Zhengzhou | Zhengzhou Xinzheng International Airport | | |
| Hong Kong | Hong Kong International Airport | | |
| Ahmedabad | Sardar Vallabhbhai Patel International Airport | | |
| Delhi | Indira Gandhi International Airport | | |
| Gaya | Gaya Airport | | |
| Jaipur | Jaipur International Airport | | |
| Kolkata | Netaji Subhas Chandra Bose International Airport | | |
| Lucknow | Chaudhary Charan Singh International Airport | | |
| Mumbai | Chhatrapati Shivaji Maharaj International Airport | | |
| Varanasi | Lal Bahadur Shastri Airport | | |
| Luang Prabang | Luang Prabang International Airport | | |
| Vientiane | Wattay International Airport | | |
| Macao | Macao International Airport | | |
| Kuala Lumpur | Kuala Lumpur International Airport | | |
| Penang | Penang International Airport | | |
| Yangon | Yangon International Airport | | |
| Mandalay | Mandalay International Airport | | |
| Kaohsiung | Kaohsiung International Airport | | |
| Bangkok | Suvarnabhumi Airport | | |
| Chiang Mai | Chiang Mai International Airport | | |
| Chiang Rai | Chiang Rai International Airport | | |
| Hat Yai | Hat Yai International Airport | | |
| Khon Kaen | Khon Kaen Airport | | |
| Krabi | Krabi International Airport | | |
| Nakhon Si Thammarat | Nakhon Si Thammarat Airport | | |
| Narathiwat | Narathiwat Airport | | |
| Phuket | Phuket International Airport | | |
| Surat Thani | Surat Thani International Airport | | |
| Ubon Ratchathani | Ubon Ratchathani Airport | | |
| Udon Thani | Udon Thani International Airport | | |
