Leukotriene-A4 hydrolase
Leukotriene A4 hydrolase, also known as LTA4H is a human gene. The protein encoded by this gene is a bifunctional enzyme which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase.Function
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds. The systematic name of this enzyme class is --5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase. Other names in common use include LTA4 hydrolase, LTA4H, and leukotriene A4 hydrolase. This enzyme participates in arachidonic acid metabolism.Structure
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and.
