LRP2
Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.Function
LRP2 was identified as the antigen of rat experimental membranous nephropathy and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2/megalin is a member of a family of receptors with structural similarities to the low density lipoprotein receptor. LRP2/megalin functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2/megalin can also form complexes with cubilin: those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin.Mutations in the LRP2 gene are associated with Donnai-Barrow syndrome.Interactions
LRP2 has been shown to interact with:
- DAB2,
- DLG4,
- GIPC1,
- ITGB1BP1,
- LDL-receptor-related protein associated protein,
- LDLRAP1,
- MAGI1,
- MAPK8IP1,
- MAPK8IP2,
- NOS1AP, and
- SYNJ2BP.
