DAB2
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.Function
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 and is distinct from the DOC2A and DOC2B genes.Interactions
DAB2 has been shown to interact with:
