He served for nine years as the director of Trees For Tomorrow, a natural resources specialty school focused primarily on conservation education for young people.
Assembly
In 1982, he successfully ran for the 46th District seat in the Wisconsin State Assembly representing Oneida and Vilas Counties. He served on the budget committee and the JointCommittee on Finance. After redistricting based on the 1980 Census, Holperin's district was re-designated as the 34th. In 1990, Holperin faced a recall effort due to his support for Native American treaty rights. At the center of the dispute was the controversy over the treaties between the federal government and the Chippewa tribe, in which the tribe ceded vast lands in northern Wisconsin in exchange for spearfishing, hunting, and timber harvesting rights. Holperin won the recall election handily, winning 61% of the vote. He retired in 1994. He was succeeded by Republican Joe Handrick.
Senate
In 2003, Governor Jim Doyle appointed him as Secretary of the Wisconsin Department of Tourism. In 2008, he ran to become a State Senator when incumbent Democratic Wisconsin State SenatorRoger Breske decided to retire after four-plus terms. He defeated Republican nominee Tom Tiffany with 51% of the vote.
2011 Union protests
During the 2011 protests in Wisconsin, Holperin, along with the 13 other Democratic State Senators, left the state on February 17 to deny the State Senate a quorum on Governor Scott Walker's controversial budget repair bill. On March 9, Republicans in the State Senate declared that they had removed all fiscal provisions from the fiscal repair bill and passed it without needing a quorum. On March 12, Holperin and the rest of the Democratic Senators returned to Wisconsin.
2011 attempted recall
Holperin was one of three Democratic state senators facing recall as a result of the 2011 Wisconsin protests. On February 22, 2011, the "Jim Holperin Recall Committee" officially registered with the Wisconsin Government Accountability Board. 15,960 valid signatures of electors residing within the 12th District were required by April 25, 2011 to generate a recall election. On March 10, 2011, supporters of the recall effort against Holperin complained of intimidation by his supporters. On April 21, 2011, Holperin recall supporters filed about 23,300 signatures on recall petitions. Holperin and Kim Simac faced off in the general recall election on August 16, 2011. Holperin won, keeping his seat.
Election 2012
In March 2012, with his district having been drastically revised by the legislature, Holperin announced he would not seek re-election in 2012. He was succeeded in the new 12th District by Republican Tom Tiffany.