Inorganic ions


Inorganic ions in animals and plants are ions necessary for vital cellular activity. In body tissues, ions are also known as electrolytes, essential for the electrical activity needed to support muscle contractions and neuron activation. They contribute to osmotic pressure of body fluids as well as performing a number of other important functions. Below is a list of some of the most important ions for living things as well as examples of their functions:

Ion Channels

K+ Channels

play a key role in maintaining the membrane's electric potential. These ion channels are present in many various biological systems. They frequently play a role in regulation of cellular level processes, many of these processes including muscle relaxation, hypertension, insulin secretion etc. Some examples of potassium ion channels within biological systems include KATP channels, Big potassium channels, and Ether-à-go-go potassium channels

Na+ Channels

provide an integral service through the body, as they transmit depolarizing impulses at the cellular and intracellular level. This allows sodium ions to coordinate much more intensive processes such as movement and cognition. Sodium ion channels consist of various subunits, however, only the principle subunit is required for function. These sodium ion channels consist of four internally homologous domains, each of which containing six transmembrane segments and resembling a single subunit of a voltage-dependent potassium ion channel. The four domains fold together, forming a central pore. That central pore of the sodium ions dictates the selectivity of the channel: both ionic radius and ionic charge are key in channel selectivity.

Cl Channels

vary from many other ion channels due to being controlled by the anionic chloride ions. Chloride ion channels are pore-forming membrane proteins that allow the passive transport of chloride ions across biological membranes. Chloride ion channels involve both voltage-gated and ligand-gated mechanisms to transport the ions across cellular membranes. Chloride ion channels have been found to play crucial roles in the development of human diseases, for example, mutations in the genes encoding chloride ion channels lead to a variety of deleterious diseases in muscle, kidney, bone, and brain, including cystic fibrosis, osteoporosis, and epilepsy, and similarly their activation is supposed to be responsible for the progression of glioma in the brain and the growth of malaria-parasite in the red blood cells. Currently, chloride ion channels are not completely understood, and more research is necessary.