Imidazolidinone
Imidazolidinones are a class of 5-membered ring heterocycles structurally related to imidazole. Imidazolidinones feature a saturated C3N2 backbones, except for the presence of a urea or amide functional group in the 2 or 4 positions.2-Imidazolidinones
The 2-imidazolidinones are cyclic ureas. 1,3-Dimethyl-2-imidazolidinone is a polar solvent and Lewis base. Drugs featuring this ring system include emicerfont, imidapril, and azlocillin. Dimethylol ethylene urea is the reagent used in permanent press clothing.4-Imidazolidinones
4-Imidazolidinones can be prepared from phenylalanine in two chemical steps ::.
Imidazolidinone catalyst work by forming an iminium ion with carbonyl groups of α,β-unsaturated aldehydes and enones in a rapid chemical equilibrium. This iminium activation lower the substrate's LUMO. Several 4-imidazolidinones have been investigated.
Drugs featuring the 4-imidazolidinone ring include hetacillin, NNC 63-0532, spiperone, and spiroxatrine.Imidazolones
Imidazolones are oxo derivatives of imidazoline. Examples include imidazol-4-one-5-propionic acid, a product of the catabolism of histidine, and imazaquin, a member of the imidazolinone class of herbicide.
