Spiperone
Spiperone is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl− channels, thus a potential target for therapy of cystic fibrosis.
| Receptor | Ki | Notes |
| 5-HT1A | 17.3 | |
| 5-HT1B | 995 | |
| 5-HT1D | 2397 | |
| 5-HT1E | 5051 | |
| 5-HT1F | 3.98 | |
| 5-HT2A | 1.17 | |
| 5-HT2B | 1114.2 | |
| 5-HT2C | 922.9 | |
| 5-HT3 | >10000 | No data available from cloned human receptors. Data comes from rat cortex receptors and other sources. |
| 5-HT5A | 2512 | Cloned mouse receptor. |
| 5-HT6 | 1590 | Cloned rat receptor. |
| 5-HT7 | 109.8 | |
| α1A | 20.4 | |
| α1B | 3.09 | |
| α1D | 8.32 | |
| D1 | 398.5 | |
| D2 | 0.16 | |
| D3 | 0.34 | |
| D4 | 1.39 | |
| D5 | 4500 | |
| H1 | 272 | |
| σ | 353 |
N-Methylspiperone is a derivate of spiperone that is used to study the dopamine and serotonin neurotransmitter system.
Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.