Talpur begun her political career in 1990s. She ran for the seat of National Assembly of Pakistan on Pakistan Peoples Party ticket from Nawabshah constituency in 1997 Pakistani general electionfor the first time, but lost the election to the Pakistan Muslim League. In 2001, she became the Nazim of district Nawabshah in local government elections. In 2005 local government elections, she was re-elected as the mayor of Nawabshah. After the assassination of Benazir Bhutto in 2007, she became legal guardian of children of Bhutto; Bilawal Bhutto Zardari, Bakhtawar Bhutto Zardari and Aseefa Bhutto Zardari and custodian of property of Bhutto in Larkana. In 2007, Talpur was considered to become a candidate of PPP for the post of President of Pakistan. Due to mayorship of Nawabshah, she was not given a ticket by PPP to run in2008 Pakistani general election. However, later in by-elections, she was allotted a ticket by PPP to run for the seat of National Assembly home constituency of Bhutto in constituency NA-207 where election was postponed due to death of Bhutto. She won in the by-elections and became member of the National Assembly for the first time. She was the central president of the women wing of PPP but reportedly she looked after almost all affairs of the PPP. Talpur is described as a tough and stubborn women. According to a WikiLeaks diplomatic cables leak in 2009, fearing attempts on his life, then President of Pakistan Asif Ali Zardari told then US Ambassador to Pakistan Anne W. Patterson that in the event he was assassinated, he had instructed his son Bilawal Bhutto Zardari to appoint Talpur as President of Pakistan. The diplomatic cable also revealed the remarks by then Chief of Army Staff of Pakistan General Ashfaq Pervaiz Kayani who said that Talpur would make a better president than Asif Ali Zardari. She was re-elected as the member of the National Assembly of the second time in 2013 Pakistani general election from NA-207 Larkana constituency. She was re-elected to Provincial Assembly of Sindh as a candidate of PPP from Constituency PS-10 in 2018 Pakistani general election.
Money Laundering
A 2015 probe by Pakistan's Federal Investigation Agency pertaining to money laundering through fake accounts resulted in the arrest of Talpur by NAB officials in Islamabad on June 14, 2019. The PPP claims that the government arrested Talpur to target the opposition. Faryal Talpur applied for bail until completion of trail in order to take care of her differently abled child. She was granted bail on December 17, 2019.
