The discovery of modern anesthesia in the 19th century was an early breakthrough in the elimination of pain during surgery, but acceptance was not universal. Some medical practitioners at the time believed that anesthesia was an artificial and harmful intervention in the body's natural response to injury. Opposition to anesthesia has since dissipated, however the prospect of eradicating pain raises similar concerns about interfering with life's natural functions. People who are naturally incapable of feeling pain or unpleasant sensations due to rare conditions like pain asymbolia or congenital insensitivity to pain have been studied to discover the biological and genetic reasons for their pain-free lives. For example, a Scottish woman with a previously unreported genetic mutation in a FAAHpseudogene with resultant elevated anandamide levels was reported in 2019 to be immune to anxiety, unable to experience fear, and insensitive to pain. The frequent burns and cuts she had due to her full hypoalgesia healed quicker than average. In 1990, Medical Hypotheses published an article by L. S. Mancini on the "genetic engineering of a world without pain": The development of gene editing techniques like CRISPR has raised the prospect that "scientists can identify the causes of certain unusual people's physical superpowers and use gene editing to grant them to others." Geneticist George Church has commented on the potential future of replacing pain with a painless sensory system:
Ethics and philosophy
Ethicists and philosophers in the schools of hedonism and utilitarianism, especially negative utilitarianism, have debated the merits of eradicating suffering. Transhumanist philosopher David Pearce, in The Hedonistic Imperative, argues that the abolition of suffering is both technically feasible and an issue of moral urgency: Nick Bostrom, director of the Future of Humanity Institute, advises a more cautious approach due to pain's function in protecting individuals from harm. However, Bostrom supports the core idea of using biotechnology to get rid of "a huge amount of unnecessary and undeserved suffering."
Animal welfare
In 2009, Adam Shriver suggested replacing animals in factory farming with genetically engineered animals with a reduced or absent capacity to suffer and feel pain. Shriver and McConnachie argued that people who wish to improve animal welfare should support gene editing in addition to plant-based diets and cultured meat. Katrien Devolder and Matthias Eggel proposed gene editing research animals to remove pain and suffering. This would be an intermediate step towards eventually stopping all experimentation on animals and adopting alternatives. Concerning wild-animal suffering, CRISPR-based gene drives have been suggested as a cost-effective way of spreading benign alleles in sexually reproducing species. To limit gene drives spreading indefinitely, the Sculpting Evolution group at the MIT Media Lab developed a self-exhausting form of CRISPR-based gene drive called a "daisy-chain drive." Also, for potential adverse effects of a gene drive, "everal genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and immunizing reversal drives."
