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Endothelin receptor antagonist
An
endothelin
receptor antagonist
is a
drug
that blocks endothelin
receptors
.
Three main
kinds
of ERAs exist:
selective
ET
A
receptor antagonists
, which affect
endothelin A receptors
.
dual antagonists, which affect both endothelin A and
B receptors
.
selective ET
B
receptor
antagonists which affect
endothelin B receptors
are used in
research
but have
not yet
reached
the
clinical trial
stage.
Sitaxentan
,
ambrisentan
and
bosentan
are mainly used for the
treatment
of
pulmonary arterial hypertension
, while
atrasentan
is an experimental
anti-cancer drug
.
Edonentan
is an
endothelin receptor
antagonist drug
.
