Ambrisentan


Ambrisentan is a drug indicated for use in the treatment of pulmonary hypertension.
The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor. Ambrisentan significantly improved exercise capacity compared with placebo in two double-blind, multicenter trials.
Ambrisentan was approved by the U.S. Food and Drug Administration and the European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension.

Recent Developments and Publications

Clinical uses

Ambrisentan is indicated for the treatment of pulmonary arterial hypertension in
patients with WHO class II or III symptoms to improve exercise capacity and delay clinical worsening.

Birth defects

Endothelin receptor activation mediates strong pulmonary vasoconstriction and positive inotropic effect on the heart. These physiologic effects are vital for the development of the fetal cardiopulmonary system. In addition to this, endothelin receptors are also known to play a role in neural crest cell migration, growth, and differentiation. As such, endothelin receptor antagonists such as Ambrisentan are known to be teratogenic.
Ambrisentan has a high risk of liver damage, and of birth defects if a woman becomes pregnant while taking it. In the U.S., doctors who prescribe it, and patients who take it, must enroll in a special program, the LETAIRIS Education and Access Program, to learn about those risks. Ambrisentan is available only through specialty pharmacies.