Dihydrofolate synthase
In enzymology, a dihydrofolate synthase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, 7,8-dihydropteroate, and L-glutamate, whereas its 3 products are ADP, phosphate, and 7,8-dihydropteroylglutamate.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases. The systematic name of this enzyme class is 7,8-dihydropteroate:L-glutamate ligase . Other names in common use include dihydrofolate synthetase, 7,8-dihydrofolate synthetase, H2-folate synthetase, 7,8-dihydropteroate:L-glutamate ligase , dihydrofolate synthetase-folylpolyglutamate synthetase, folylpoly- synthetase-dihydrofolate synthase, FHFS, FHFS/FPGS, dihydropteroate:L-glutamate ligase , and DHFS. This enzyme participates in folate biosynthesis.As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and.
