Levy played college football at Wisconsin from 2005 to 2008. He finished his career with 211 tackles, 21 sacks, two interceptions, six forced fumbles, six fumble recoveries and a blocked kick. In November 2006, Levy inadvertently collided with nearly 80-year-old Penn State coach Joe Paterno on the sideline during a game, fracturing Paterno's shin bone and damaging knee ligaments. Subsequent to the Penn State child sex abuse scandal, Levy now calls that incident "my proudest moment in college". In response, 21 former Penn State football players signed a letter condemning his comments. Levy was named second-team All-Big Ten in 2007. In 2008, he earned honorable mention All-Big Ten, and was also awarded the team's Tom Wiesner Award, given to a senior football player who most exemplifies the leadership and courage. In addition to twice winning the Big 10Player of the Week, in 2008, he was also awarded the Bronko Nagurski National Defensive Player of the Week on September 13 for his performance against Fresno St.
Professional career
Levy was drafted by the Lions in the third round of the 2009 NFL Draft. As a rookie, Levy started 10 of 16 games for the Detroit Lions, recording 85 tackles and an interception. In 2010, Levy was limited to only 11 games, missing Detroit's Week 1, 2, 4, 5, and 6 games. For the season, Levy recorded 72 tackles, 2 interceptions, and 4 pass-breakups. In Week 14, against the eventual Super Bowl ChampionGreen Bay Packers, Levy had 8 tackles and an interception of Packers QB Matt Flynn in the endzone in a 7-3 Lions win. In Week 16, against the Miami Dolphins, Levy returned an interception of Chad Henne 30 yards for the game-winning touchdown in a 34-27 win. In his third season in 2011, Levy started all 16 games for the Lions, recording 109 tackles, a sack, an interception, and a forced fumble. In 2012, Levy started 13 games for the Lions, recording 82 tackles, and 1 interception. In 2013, Levy started all 16 games for the Lions, recording 119 tackles, and 6 interceptions. In 2014, Levy started all 16 games for the Lions, recording 151 tackles, 2.5 sacks, and 1 interception. On August 5, 2015, it was announced that Levy and the Detroit Lions agreed on a four-year extension. Levy only played 1 game in the 2015 season due to injury. In 2016, Levy's playing time was limited due to a torn meniscus he suffered at the beginning of the 2016 season. On March 9, 2017, with two years left on his contract, he was released by the Lions. He filed an injury grievance against the Lions in August.
Personal life
Levy continues to reside in the Detroit area with his wife Desiré, whom he met in college and married in 2016. Since retiring, and while still a player, he has been an advocate for victims of sexual assault. In April 2016, DeAndre wrote a column for The Players' Tribune encouraging men and especially professional athletes to take leadership in sexual assault prevention. Not only did players respond in support of his article, but victims also reached out and shared their stories. The couple commissioned a mural in Eastern Market in 2017 to encourage survivors of sexual assault and harassment to open up about their stories. They have also led fundraising efforts for related causes and organizations, such as Enough SAID. Levy also spoke out about the NFL's stance on the link between professional football and brain injuries in 2016, taking the NFL to task via a letter and various Instagram posts. He called for greater transparency about the risks of playing professional football, though he made it clear that he still wanted others to enjoy playing.