d'Arnaud made his professional baseball debut in 2008, playing for the State College Spikes. In 2009, he played for the West Virginia Power and the Lynchburg Hillcats. In 2010, he played for the Altoona Curve. In 2011, d'Arnaud was playing for the Indianapolis Indians when he was called up to the majors by the Pittsburgh Pirates for the first time on June 24. In his major league debut, he recorded his first major league hit, a triple, off Boston Red Sox pitcher Jon Lester. d'Arnaud appeared in 48 games for the Pirates in 2011, batting.217, with six runs batted in and 12 stolen bases. In 2012, d'Arnaud played 98 games for Indianapolis, batting.252 with 34 stolen bases. He was recalled by the Pirates on September 10, 2012. He played eight games for the Pirates in 2012, scoring a pair of runs and getting a stolen base. On March 20, 2013, the Pirates placed d'Arnaud on the 60-day disabled list after surgery to repair a partially torn ligament in his left thumb. d'Arnaud started a rehab assignment with the Bradenton Marauders on May 16. On May 18, his rehab assignment was transferred to the Altoona Curve, and then to the Indianapolis Indians on May 25. He was activated from the disabled list and optioned to Indianapolis on May 31, where he played the rest of the season. d'Arnaud was designated for assignment on February 24, 2014 when Brent Morel was claimed on waivers from the Toronto Blue Jays. He spent the season with Indianapolis, and his contract was selected by the Pirates on September 2 after the rosters expanded. He appeared in eight games for the Pirates in 2014, and was used as a pinch runner and defensive replacement. On November 3, he was outrighted to Indianapolis, and elected free agency.
Philadelphia Phillies
On November 13, 2014 d'Arnaud signed a minor league deal with the Philadelphia Phillies. He spent the 2015 minor league season with the Triple-ALehigh Valley IronPigs. His contract was selected by the Phillies from Lehigh Valley on September 14, 2015.
Atlanta Braves
On November 24, 2015, d'Arnaud signed a minor league contract with the Atlanta Braves. d'Arnaud was designated for assignment on April 25, 2017.
Boston Red Sox
He was claimed by the Boston Red Sox on April 27. d'Arnaud was designated for assignment on May 18, 2017.
San Diego Padres
On May 21, 2017, he was claimed by the San Diego Padres.
On December 17, 2018, d'Arnaud signed a minor league contract with the Texas Rangers. He was assigned to the Triple-A Nashville Sounds to open the 2019 season. He was released on June 18.
On June 21, 2019, d’Arnaud signed a minor league deal with the Kansas City Royals. He became a free agent following the 2019 season. On February 17, 2020, d’Arnaud announced his retirement from baseball via Instagram. However, the retirement was short-lived as he made himself available to play for the Philippines in the 2021 World Baseball Classic qualifiers to be held in Tucson, Arizona from March 20 to 25, 2020. His mother Marita is a Filipina.
Personal
He is the son of Lance and Marita d’Arnaud. His brother, Travis d'Arnaud, is a catcher for the Atlanta Braves. d'Arnaud is also known for his musical pursuits. In summer 2016 he performed at Bonnaroo Music Festival.
