Carbamoyl phosphate synthase II
Carbamoyl phosphate synthetase II is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol. Its systemic name is hydrogen-carbonate:L-glutamine amido-ligase .
In pyrimidine biosynthesis, it serves as the rate-limiting enzyme and catalyzes the following reaction:
It is activated by ATP and PRPP and it is inhibited by UMP.
Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions.
It is one of the three enzyme functions coded by the CAD gene. It is classified under.Nomenclature
Carbamoyl-phosphate synthetase is also known as:
