Carbamoyl phosphate
Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines. Its enzymatic counterpart, carbamoyl phosphate synthetase I, interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate. CP then enters the urea cycle in which it reacts with ornithine to form citrulline. A defect in the CPS I enzyme, and a subsequent deficiency in the production of carbamoyl phosphate has been linked to hyper-ammonemia in humans.Production
It is produced from bicarbonate, ammonia, and phosphate. The synthesis is catalyzed by the enzyme carbamoyl phosphate synthetase, as follows:
- + ATP → ADP +
- + NH3 + OH− → + −O–CNH2 + H2O
- −O–CNH2 + ATP → ADP +
