Antikyra has been identified with the Cyparissus which appears in the Homeric Catalogue of Ships as the primary port of ancient Phocis. It became known as Antikirrha or Anticirrha from its position on the opposite side of a peninsula from Cirrha, Delphi's port on the Gulf of Corinth. This name then became Antikyrrha or Anticyrrha and then Antikyra. The last was followed by the Romans, Latinized as Anticyra. During its period under the Catalans, it was known as. Under the Ottomans, it became known as for its white houses but its former name was restored in the early 20th century. Under the former BGN/PCGN standard, it was romanized as Andikira in America and the United Kingdom until 1996.
It was a town of considerable importance in ancient times. In antiquity, Antikyra was associated with the still-older settlement of Kyparissos which was noted as the primary port of Mycenaean Phocis in Homer's Iliad. The name literally means "cypress" but was glossed as deriving from the town's mythical founder Cyparissus, son of Orchomenus and brother of Minyas. The Catalogue of Ships states the Phocians who joined the Trojan War sailed from Kyparissos to join the main fleet at Aulis before it sailed for Troy. The reputed graves of the heroesSchedios and Epistrophos, the Phocian admirals, were maintained through Roman times. The name Antikyra was said to have derived from an "Antikyreos" or "Anticyreus" who cured Hercules's insanity with local hellebore. Black and white hellebore were the main reason for the town's fame in the ancient world. Both grew nearby and were regarded by Greek medicine as cures for forms of insanity, melancholy, gout, and epilepsy. The circumstance gave rise to a number of Greek and Latin expressions, like Αντικυρας σε δει or "naviget Anticyram," and to frequent allusions in Greek and Roman literature. Pausanias claims that black hellebore was used as a laxative, whilst white hellebore was used as an emetic. Antikyra was destroyed in 346 by Philip II of Macedon amid the Third Sacred War. It recovered enough to quickly begin construction of a temple to Artemis with a cult statue commissioned to Praxiteles by 330 . Antikyra was then besieged, destroyed, and rebuilt several times during the Roman Republic's Macedonian Wars. In 198 , it was sacked by Titus Quinctius Flamininus, who choose it as winter base for his army. During the 2nd century , Antikyra struck autonomous bronze coins with the head of Poseidon on the obverse and Artemis bearing a torch and an arch on the reverse. Pausanias visited the city during the third quarter of the 2nd century and gave a detailed account of it in his Description of Greece. He notes the grave of Schedios and Epistrophos, a temple to Poseidon with a bronze statue of the god standing with one foot resting on a dolphin, a hand upon this thigh and a trident in his other hand, two gymnasia, an agora with many bronze statues, a sheltered well, and two temples of Artemis outside the town walls. One was dedicated to Artemis Diktynna; the other held Praxiteles's sculpture and, according to a newly discovered inscription, was dedicated to Artemis Eileithyia.
Medieval
Under the Byzantines, the city served as a bishopric. A large earthquake destroyed most of the city around 620. During the 14th century, the city was named Port de Arago while its fortress was held by the Catalans, probably under the aegis of the county of Salona. It became known as Aspra Spitia or Asprospitia under the Turks.
Modern
Aspra Spitia's connection with the ancient Antikyra was established by William Martin Leake in 1806 when he found an inscription mentioning its name. The area was subsequently excavated by Lolling, Dittenberger, Fossey, the 10th Archaeological Ephorate, and the 1st Byzantine Ephorate. During this period, an archaic temple of Athena was discovered, along with its severe style bronze idol, a large part of the 4th-century ashlar fortification with 2 rectangular towers, and an early Christian bath with a hypocaust. In 1836, after Greek independence, the municipality Antikyraia was established, containing the villages Desfina, Aspra Spitia and Moni Agiou Ioannou Prodromou. In 1912, the municipality was replaced by the new community Desfina. Antikyra became a separate community in 1929, but was merged back into Desfina in 1935. The community Antikyra was re-established in 1943. In the 1950s and '60s, Aluminum of Greece developed the country's largest aluminum plant to exploit nearby bauxite deposits. A new town was developed for its workers under the name Aspra Spitia; this is now known as Paralia Distomou. Greenpeace has complained of the effects of the red mud dumped into the bay from the plant. At the 2010 Kallikratis reform, Antikyra was merged with its neighbors to form Distomo-Arachova-Antikyra.