Anthranilate synthase


In enzymology, an anthranilate synthase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its 3 products are anthranilate, pyruvate, and L-glutamate.

Function

Reaction

In enzymology, an anthranilate synthase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its 3 products are anthranilate, pyruvate, and L-glutamate.

Structure and assembly

The complex is made up of α and β subunits. Gel filtration experiments reveal that the complex occurs as an α2β2 tetramer under native conditions, and as an αβ dimer under high salt concentrations. The αβ dimers interact through the α subunits to form the complex.

Homologs

Paralogs

Nomenclature

This enzyme belongs to the family of lyases, to be specific the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is chorismate pyruvate-lyase . Other names in common use include anthranilate synthetase, chorismate lyase, and chorismate pyruvate-lyase . This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and.

Application