Humphries played 53 games and started 27 of them for Clemson from 2011 to 2014. Through his college career, he had a total of 127 receptions for 1,097 yards and three touchdowns, as well as 10 carries for 24 yards and one touchdown and 69 punt returns for 476 yards and one touchdown.
Collegiate statistics
Professional career
Coming out of Clemson, Humphries was projected by the majority of analysts to go undrafted and to be signed as a priority undrafted free agent. He was ranked the 144th best wide receiver out of the 351 available by NFLDraftScout.com. He was not invited to the NFL Scouting Combine but was able to show his abilities in front of scouts and representatives from all 32 NFL teams at Clemson's annual Pro Day.
Humphries went undrafted in the 2015 NFL Draft, but accepted an invitation to attend rookie minicamp with the Tampa Bay Buccaneers. On May 11, 2015, the Tampa Bay Buccaneers signed Humphries to a three-year, $1.57 million contract that includes a signing bonus of $19,800. He entered training camp competing to be the Buccaneers' fifth wide receiver on their depth chart with Robert Herron, Donteea Dye, Rannell Hall, Tavarres King, and Kaelin Clay. On September 6, 2015, it was announced that Humphries had made the 53-man roster and would be a punt/kick returner and the Buccaneer's fifth wide receiver behind veterans Vincent Jackson, Mike Evans, Louis Murphy, and Russell Shepard. Humphries made his NFL debut in the Buccaneers' season opener against the Tennessee Titans and finished the loss with two receptions for 14 yards. On October 5, 2015, the Buccaneers waived Humphries and consequently signed him to their practice squad on October 7, 2015. After injuries to Buccaneer wide receivers Vincent Jackson and Russell Shepard, it was announced on October 28, 2015 that Humphries and Donteea Dye had been added to the active roster. On December 13, 2015, Humphries caught his first career touchdown reception on a six-yard pass from Jameis Winston, during a 17-24 loss to the New Orleans Saints. On December 17, 2015, he caught a season-high six passes for 60 receiving yards in a 23-31 loss to the St. Louis Rams. Humphries finished his rookie year with 13 game appearances, 27 receptions for 260 yards and a receiving touchdown.
2016 season
Humphries entered training camp competing with Russell Shepard and Kenny Bell to be the Buccaneers' third wide receiver under new head coachDirk Koetter. On August 1, 2016, head coach Dirk Koetter named Humphries the team's third receiver. Humphries earned his first NFL start in the Buccaneers' season opener against the Atlanta Falcons and finished the 31-24 victory with three catches for 34 yards and one carry for seven yards. On September 25, 2016, Humphries caught a season-high nine passes for 100 yards in a 32-37 loss to the Los Angeles Rams. It was the first game with over 100 receiving yards of his career. During a Week 9 matchup against the Falcons, he caught five receptions for 46 yards and his first touchdown of the season on a seven-yard pass from Jameis Winston during a 28-43 loss. On December 18, 2016, Humphries caught two passes for 49 yards and a season-long 42 yard touchdown reception against the Dallas Cowboys. In Week 17, against the Carolina Panthers, Humphries had a career-high 10 receptions for 94 yards. Humphries finished his second year with 15 game and four starts and 55 receptions for 622 yards and three touchdowns.
2017 season
On February 27, 2017, Humphries signed a one-year guaranteed contract tender with the Buccaneers worth $615,000. Humphries entered the season third on the wide receiver depth chart behind Mike Evans and DeSean Jackson. Humphries finished the season with a career-high 61 receptions for 631 yards and a touchdown.
2018 season
On March 12, 2018, the Buccaneers placed a second-round restricted free agent tender on Humphries. In a Week 6 loss to the Atlanta Falcons, he had three catches for 82 yards, including a career-long 51-yard reception. In a Week 9 loss against the Carolina Panthers, Humphries caught eight passes for 82 yards and a career-high two touchdowns. In a Week 11 loss to the New York Giants, Humphries had three catches for 60 yards and a touchdown. In a Week 12 win over the San Francisco 49ers, he caught six passes for 50 yards and a touchdown. In a Week 13 win over the Carolina Panthers, Humphries caught seven passes for 61 yards and a touchdown. In a Week 16 loss to the Dallas Cowboys, he had 10 catches for 79 yards. Humphries finished 2018 with career highs in receptions, receiving yards, and touchdowns, recording 76 receptions for 816 yards and five touchdowns.
Tennessee Titans
On March 14, 2019, Humphries signed a four-year, $36 million contract with the Tennessee Titans.
2019 season
During a Week 10 35-32 victory against the Kansas City Chiefs, Humphries caught his first touchdown of the season on a 23-yard reception from Ryan Tannehill, which proved to be the game-winner. In the next game against the Indianapolis Colts, Humphries caught his second touchdown of the season on a 13-yard reception in the 31-17 road victory. Overall, Humphries finished the 2019 season with 37 receptions for 374 receiving yards and two receiving touchdowns.
