6,7-dihydropteridine reductase


In enzymology, a 6,7-dihydropteridine reductase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are a 5,6,7,8-tetrahydropteridine, NAD+, and NADP+, whereas its 4 products are a 6,7-dihydropteridine, NADH, NADPH, and H+.
This enzyme participates in folate biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NADH oxidoreductase, DHPR, NADH:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine, reductase, dihydropteridine reductase, dihydropteridine reductase, and 5,6,7,8-tetrahydropteridine:NADH+ oxidoreductase.

Clinical significance

is a defect in the regeneration of tetrahydrobiopterin. Many patients have significant developmental delays despite therapy, develop brain abnormalities, and are prone to sudden death. The reason is not completely clear, but might be related to the accumulation of dihydrobiopterin and abnormal metabolism of folic acid. Response to treatment is variable and the long-term and functional outcome is unknown. To provide a basis for improving the understanding of the epidemiology, genotype/phenotype correlation and outcome of these diseases their impact on the quality of life of patients, and for evaluating diagnostic and therapeutic strategies a patient registry was established by the noncommercial International Working Group on Neurotransmitter Related Disorders. Dihydrobiopterin reductase deficiency is treated with tyrosine supplements, a controlled diet which is lacking in phenylalanine, well as supplementation of L-DOPA.