Year 246 BC was a year of the pre-Julian Roman calendar. At the time it was known as the Year of the Consulship of Crassus and Licinus. The denomination 246 BC for this year has been used since the early medieval period, when the Anno Dominicalendar era became the prevalent method in Europe for naming years.
Egypt'sPtolemy II dies and is succeeded by his son, Ptolemy III. At the time of Ptolemy II's death, Egypt comprises the ancient kingdom of Egypt in the Nile Valley, Cyrene, Judea and the coast of southern Syria, Cyprus and a number of cities on the shores and islands of the Aegean Sea. The Macedonian Ptolemies maintain their authority over their territories with a small mercenary army made up of Macedonians and other Greeks.
Antiochus II leaves Berenice in order to live again with his former wife Laodice and his son Seleucus. However, Laodice poisons him and proclaims her son as King Seleucus II Callinicus, while her supporters in Antioch kill Berenice and her children who have taken refuge at Daphne, near Antioch, in Syria.
Berenice's brother, Ptolemy III, sets about to avenge his sister's murder by invading Syria which begins the Third Syrian War. Ptolemy III's navy, perhaps with the aid of rebels in the cities, advances against Seleucus II's forces as far as Thrace, across the Hellespont, and also captures some islands off the Anatolian coast.
Seleucus II Callinicus' mother, Laodice attempts to take control over the Seleucid Empire by insisting that Seleucus II make his younger brother, Antiochus Hierax, co-regent and give him all the Seleucid territory in Anatolia. Antiochus promptly declares independence and begins fighting a war with his brother.
In order to secure the Bactrian King Diodotus' friendship, Seleucus II Callinicus arranges the marriage of one of his sisters to King Diodotus.
In Rome, the number of praetors is increased from one to two. The second praetor is appointed to relieve the backlog of judicial business and to give the Republic a magistrate with Imperium who can field an army in an emergency when both consuls are away fighting a war.
Antiochus II Theos, king of the Seleucid dominions in the Middle East from 261 BC. He has spent much of his reign at war with Egypt, recovering much of the territory in Anatolia lost in earlier wars between the Ptolemaic and Seleucid dynasties
Berenice, daughter of Ptolemy II Philadelphus and Arsinoe, wife of the Seleucid ruler Antiochus II Theos, supplanting his first wife, Laodice, whose children she has persuaded him to bar from the succession to the throne in favour of her own.