2-dehydro-3-deoxyglucarate aldolase


In enzymology, a 2-dehydro-3-deoxyglucarate aldolase is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-glucarate, and two products, pyruvate and tartronate semialdehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase . Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and.