Xuong Nguyen-Huu is a pioneer of protein crystallography technology. His research focuses on the development of novel methods, such as protein crystallography and cryo-electron microscopy, for the determination of protein structures and biological macromolecules.
Career
Nguyen received his B.S.E.E. in electrical engineering; M.S.E.E. from Ecole Superieure d'Electricite, Paris, France ; M.S. in Mathematics from University of Paris, Paris ; M.S. and Ph.D. in Physics from the University of California, Berkeley. He is a Professor Emeritus of Physics, Biology, Chemistry & Biochemistry at UC San Diego since 1964. He is a pioneer of protein crystallography technology and of the field of Direct Detection Device that will be used in Electron Microscopy. He is also inventor of "Xuong’s X-Ray Machine" in 1975, an X-ray Multiwire Area Detector, which using Multi-wire Proportional Chambers and then Silicon detectors to help researchers map three-dimensional structure of receptor and allowed for high-speed data collection, and can be used to find drugs to kill deadly viruses such as HIV. His awards include Guggenheim Fellowship, NATO Senior Fellowship, Fogerty Fellowship, Union of Pacific Asian Communities Award, UCSD Chancellor Associate Award and Charles E. Supper Instrumentation Award from American Crystallographic Association. He is also founder of Area Detector Systems Corporation He served as the President of the Vietnamese Alliance Association, 1976–1992 and was also Co-Founder and Ex-Chairman of "Boat People SOS Committee" from 1980 to 1990, which worked with another non-profit organizations to obtain visas for Vietnamese refugees and they successfully sent out rescue ships on the South China Sea to pick up drifting boat people, saving more than 3,500.
The Structures of Anthranilate Synthase of Serratia Marcescens Crystallized in the Presence of its substrates, Chorismate and Glutamine, and a Product, Glutamate, and its End-product Inhibitor, L-tryptophan. With G. Spraggon, C. Kim, M. C. Yee, C. Yanofsky, and S. E. Mills. PNAS 98, 6021 2001.
Status of the Digital Pixel Array Detector for Protein Crystallography. With P. Datte, A. Birkbeck, E. Beuville, N. Enres, F. Druillole, L. Luo, and J. Millaud. Nuclear Instru. & Methods Phys. Res. A-421, 576 1999.
ASIC-Based Event-Driven 2D Digital Electron Counter for TEM Imaging. With G.Y. Fan, P. Datte, E. Beuville, J.-F. Beche, J. Millaud, K.H. Downing, F.T. Burkard, and M.H. Ellisman. Ultramicroscopy 70, 107 1998.
