XAF1
XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.Function
X-linked inhibitor of apoptosis is a potent member of the IAP family. All members of this family possess baculoviral IAP repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases. XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells.Interactions
XAF1 has been shown to interact with XIAP.
