In 1952, Wu became a faculty member at the Department of Architecture of Tongji University in Shanghai. Dai Fudong, her classmate at National Central University, was also assigned to Tongji, and they married the following year. In 1958, Wu, Dai, and their colleague Fu Xinqi were appointed co-designers of the Meiling Guesthouse at the East Lake in Wuhan. Half way through the project, they were invited to watch a show with Mao Zedong, and were told that the guesthouse was Mao's personal villa in Wuhan. Mao spent much of his later years at Meiling. Wu and Dai did not see the completed building until 1978, when it was opened to the public as a tourist attraction after Mao's death. After 1972, she worked for the Institute of Architectural Design and Research of Tongji University. Wu and her husband collaborated on nearly 100 projects. They specialized in small and medium-sized buildings including offices, hotels, and university buildings. They emphasized the use of local materials, strove to utilize limited resources for the maximum benefit, and focused on human comfort and artistic value. In an interview with Chinese media, Wu stated that Dai mainly focused on the overall design, and she on the detailed execution. In 1988, Wu and Dai designed the architecture school of Tongji University. At the time Chinese universities were poorly financed; they were given a budget of only US$570,000 for the building. The building was well received, and they were subsequently commissioned to design the university's Run Run Shaw Building and the Graduate School Building. In 1992–1993, Wu and Dai designed the Big DipperMountain Village, a small hotel on the Shandong Peninsula with seven buildings. The buildings had modern interiors, but externally they were covered with local stones and roofs were covered with seaweed, a material used by local farmers for the roofs of their houses, and the pathways were paved with local pebbles with grass planted among them. Their design minimized the cost while giving the hotel a distinct local flavour. They also applied the same design philosophy to the International Hotel in Zunhua. Wu has been awarded 12 national, ministerial, and municipal prizes for her designs. In May 2004, she was named by the Ministry of Construction of China as a "National Master of Engineering and Design".
