Sancroft was born at Ufford Hall in Fressingfield, Suffolk, son of Francis Sandcroft and Margaret Sandcroft née Butcher. He was educated at the Bury St Edmunds free grammar school before being admitted to Emmanuel College, Cambridge, in September 1633 and matriculating there in 1634. His uncle William Sancroft the Elder was then master of the college. He graduated B.A. in 1638, M.A. in 1641 and became a fellow in 1642, but was ejected in 1649 for refusing to accept the "Engagement". He then remained abroad till the Restoration, after which he was chosen one of the university preachers, and was elected Master of his alma materEmmanuel College, Cambridge in 1662, serving until 1665. In 1663 was nominated to the deanery of York. He became Dean of St Paul's in 1664, greatly assisting with the rebuilding after the Great Fire of London, towards which he contributed £1400. He also rebuilt the deanery, and improved its revenue. He was criticized for leaving London during the Great Plague of 1665, though in his defence it must be said that virtually all of the upper class did the same. In 1668 he was admitted Archdeacon of Canterbury upon the king's presentation, but he resigned the post in 1670. In 1677, being now prolocutor of the Convocation, he was unexpectedly advanced to the archbishopric of Canterbury, at the express wish of the King, who trusted in his moderation. So unwilling was he to accept that the King only persuaded him by explaining that he had already appointed the new Dean of St Paul's. He attended Charles II upon his deathbed, and "made to him a very weighty exhortation, in which he used a good degree of freedom." He crowned King James II in 1685. Sancroft wrote with his own hand the petition presented in 1688 against the reading of the Declaration of Indulgence, which was signed by himself and six of his suffragans. For this they were all committed to the Tower of London, but were acquitted.
Nonjuring schism
Upon the withdrawal of James II he concurred with the Lords in a declaration to William III for a free parliament, and due indulgence to the Protestant dissenters. But, when William and his wife Mary were declared king and queen, he refused to take the oath to them, and was accordingly suspended and deprived in 1690. In August 1690 John Tillotson took over his duties. In April 1691 Tillotson officially became Sancroft's successor. Many years after it was composed, John Overall's Convocation Book was published by Sancroft, to justify the principles of his Nonjuring party. The book was "on the subject of Government, the divine institution of which was very positively asserted." It consisted partly of canons and partly of introductory and explanatory dissertations on the matter of the canons and had been duly sanctioned in the Convocation of 1610. It was, however, a strange oversight in Sancroft's party to publish the book, as there are several canons in it which clearly lay down that a de facto government is, when completely established, to be held in the light of a de jure government; and it was upon the very grounds set forth in this book that Sherlock took the oaths to King William. Sancroft was a patron of Henry Wharton, the divine and church historian, to whom on his deathbed he entrusted his manuscripts and the remains of Archbishop Laud. From 5 August 1691 until his death two years later, he lived a very retired life in his native village of Fressingfield. He died at his family home, Ufford Hall, and was buried in the churchyard of Fressingfield, where there is a Latin epitaph to his memory.