SR 134 begins at an intersection with US 60 and SR 143 at the west end of downtown Hampton; Armistead Avenue heads south from the intersection as an unnumbered street. SR 134 heads north as four-lane divided Armistead Avenue, which intersects SR 351 and the Phoebus Branch of CSX's Peninsula Subdivision before reaching I-64. All connections between SR 134 and I-64 are accounted for through intersections with Rip Rap Road, which the highway intersects just north of the railroad crossing; La Salle Avenue, which the highway meets just north of the I-64 overpass; and direct ramps to the north of La Salle Avenue. North of La Salle Avenue, SR 134 crosses Newmarket Creek and intersects US 258. Armistead Avenue continues north as an unnumbered street while the state highway turns west onto eight-lane Mercury Boulevard. SR 134 and US 258 head west through a commercial area where the highways meet the eastern end of SR 152 and intersect Coliseum Drive, which leads south to the Hampton Coliseum and north to Peninsula Town Center. SR 134 leaves US 258 at the highways' interchange with I-64, a partial cloverleaf interchange with flyover ramps from eastbound I-64 to southbound SR 134 and from eastbound US 258 to westbound I-64. SR 134 runs concurrently with I-64 west to the partial interchange where the state highway exits to the north. That interchange includes a ramp from southbound SR 134 to westbound SR 152, which I-64 crosses while it is concurrent with SR 134. SR 134 continues north as Magruder Boulevard, a four-lane divided highway named for Confederate General John B. Magruder. North of its single-point urban interchange with Hampton Roads Center Parkway, the state highway continues through a forested area and has a partial cloverleaf interchange with SR 172, which provides access to Langley Research Center and Langley Air Force Base. SR 134 veers northwest and crosses Brick Kiln Creek into York County. The state highway continues as Hampton Highway, which has intersections with SR 600 and SR 171 before reaching its northern terminus at a trumpet interchange with US 17 in the community of Tabb.