It has been shown that uranium hexafluoride is an oxidant and a Lewis acid that is able to bind to fluoride; for instance, the reaction of copper fluoride with uranium hexafluoride in acetonitrile is reported to form copper heptafluorouranate, Cu2. Polymeric uranium fluorides containing organic cations have been isolated and characterised by X-ray diffraction.
UF6 is used in both of the main uranium enrichment methods — gaseous diffusion and the gas centrifuge method — because its triple point is at temperature 64.05 °C and only slightly higher than normal atmospheric pressure. Fluorine has only a single naturally occurringstable isotope, so isotopologues of UF6 differ in their molecular weight based solely on the uranium isotope present. All the other uranium fluorides are nonvolatile solids that are coordination polymers. Gaseous diffusion requires about 60 times as much energy as the gas centrifuge process: gaseous diffusion-produced nuclear fuel produces 25 times more energy than is used in the diffusion process, while centrifuge-produced fuel produces 1,500 times more energy than is used in the centrifuge process. In addition to its use in enrichment, uranium hexafluoride has been used in an advanced reprocessing method, which was developed in the Czech Republic. In this process, used oxide nuclear fuel is treated with fluorine gas to form a mixture of fluorides. This mixture is then distilled to separate the different classes of material. Uranium enrichment produces large quantities of depleted uranium hexafluoride, or DUF6, as a waste product. The long-term storage of DUF6 presents environmental, health, and safety risks because of its chemical instability. When UF6 is exposed to moist air, it reacts with the water in the air to produce UO2F2 and HF both of which are highly corrosive and toxic. In 2005, 686,500 tonnes of DUF6 was housed in 57,122 storage cylinders located near Portsmouth, Ohio; Oak Ridge, Tennessee; and Paducah, Kentucky. Storage cylinders must be regularly inspected for signs of corrosion and leaks. The estimated lifetime of the steel cylinders is measured in decades. There have been several accidents involving uranium hexafluoride in the US, including a cylinder-filling accident and material release at the Sequoyah Fuels Corporation in 1986. The U.S. government has been converting DUF6 to solid uranium oxides for disposal. Such disposal of the entire DUF6 inventory could cost anywhere from $15 million to $450 million.