Born in Valletta of judge Gio Batta Mifsud and Philomena Marianna Muscat, Ugo P. Mifsud studied at Malta's Lyceum and Royal University, graduating as a lawyer in 1910. He married Maria Beatrice Francia in 1928. Specialised in international law, Ugo P. Mifsud published in leading international journals such as the London International Law Notes and was appointed a member of the International Law Association, set up in Brussels, actively participating in its two-yearly international conferences. In 1928 Mifsud chaired the aerial and radio law committee at a conference in Warsaw, and represented Malta at a conference of the Empire Parliamentary Association in Canada. In 1934 he chaired the trade marks committee at a conference in Budapest. When Sir Filippo Sciberras rallied a Maltese legislative assembly to draft a liberal Constitution to submit to the British colonial government, Mifsud was elected secretary of the sitting. At the 1921 elections under the Amery-Milner Constitution, Mifsud was elected to Parliament for the Unione Politica Maltese for the Legislative Assembly. In 1924, at 35, Mifsud succeeded to Francesco Buhagiar, becoming the youngest Prime Minister in the British Empire. Following the merger of the UPM with Enrico Mizzi's PDN, in 1926 Mifsud became co-leader of the newly formed Partito Nazionalista. In 1927 he was knighted. At the 1927 and 1932 elections Mifsud was re-elected in a landslide, holding again the premiership till 1933, when the 1921 Constitution was withdrawn by the colonial authorities. During this term, in 1932, he travelled with a delegation to London to submit a memorandum to the Secretary of State for the Colonies, Sir Philip Cunliffe Lister, with a formal request for Malta to be placed under the Dominions Office as an independent member of the Commonwealth. Mifsud also held several ministerial portfolios in the same period: Minister for Agriculture and Fisheries, Minister for Posts, Minister for Industry and Commerce, Minister of Finance, Minister of Justice. In 1939 Mifsud was elected Member of the Council of Government. The only Nationalist MP in Parliament during the second world war, he vehemently opposed the deportation and internment in Uganda of fellow Maltese politicians accused of anti-British and pro-Italian activities, including Enrico Mizzi. On 9 February 1942 as the Council was debating, as a matter of urgency, the British Government's intention to deport several Maltese citizens, Mifsud suffered a heart attack as he was delivering a speech against the government's intention. Two days later he died. He is buried at the Lija cemetery. On the 21st anniversary of his death a marble monument at Floriana was erected to his memory.