UVRAG
UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PIKC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.
Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
