After shakedown, Shubrick sailed for North Africa with a large convoy on 8 June 1943. Reaching her destination, she prepared for Operation Husky and, on 10 July, provided fire support for the Amphibious Battle of Gela, Sicily. She engaged enemy shore batteries and broke up an enemy tank concentration, then retired to protect the transports offshore. On 11 and 12 July, she shot down two aircraft. After two trips to Bizerte and another period of shore bombardment, she escorted the cruiser to Palermo. There, during a night air raid on 4 August, Shubrick was hit amidships by a bomb which caused flooding of two main machinery spaces and left the ship without power. Nine were killed and 20 wounded in the attack. The damaged destroyer was towed by into the inner harbor for emergency repairs and then to Malta for drydocking. Using one screw, the ship returned to the United States, arriving in New York on 9 October for permanent repairs.
Operation Overlord
After completion of repairs and refresher training in January 1944, Shubrick made two convoy runs to Europe and back before joining the Normandy bombardment group in Belfast. After escorting the battleship and five cruisers to the Normandy beaches Shubrick took her own fire support station and, at 05:50 on 6 June, opened fire on her preassigned targets. She continued her fire as the troops landed, then checked her fire at 06:30 to avoid hitting friendly forces. A third battery of German field cannon, part of the Maisy battery complex between Omaha and Utah landing beaches was targeted and destroyed by Shubrick on 8 June 1944. She remained off the Normandy beaches for over a month, performing escort duties, fire support missions and anti-motor torpedo boat and anti-submarine patrols, with trips to England for replenishment. On 27 June, she escorted six American PT boats to Cherbourg. There, the patrol craft reconnoitered enemy defenses by drawing their fire. Shubrick herself came under fire before the mission was completed. She left Normandy for the last time on 11 July and, five days later, joined a task group bound for the Mediterranean.
Operation Dragoon
On 12 August, Shubrick sailed from Malta with four escort carriers and five other destroyers to provide air cover for the landings in southern France on 15 August. Aside from float lights dropped on the evening after the landings, the force encountered no enemy opposition and was disbanded on 30 August. On 6 September, Shubrick sailed from Oran for overhaul in the United States.
Transfer to Pacific
After overhaul, Shubrick made a convoy trip to Taranto, Italy, and then conducted training along the east coast of the United States. On 1 February 1945, she transited the Panama Canal to join the U.S. Pacific Fleet. After additional training, she departed from Pearl Harbor on 21 April escorting the battleship to Okinawa. On 12 May, she and one other destroyer supported the landings at Tori Shima and shot down two attacking aircraft. Shubrick completed one radar picket patrol in mid-May, but, on her way to her second, she was attacked at 00:10, 29 May 1945, by two kamikaze aircraft, one of which crashed into the ship. The bomb carried by the plane blew a hole in the starboard side, and further damage was done when one of the ship's depth charges exploded. At first the situation looked grim. The destroyer came alongside at 01:13 and removed classified material and all wounded and unnecessary personnel. However, the crew finally controlled the flooding, and Shubrick was towed to Kerama Retto by. The ship lost 35 men killed and missing, and 25 wounded in the attack.
Shubrick underwent emergency repairs until 15 July, when she began the trip back to the United States on one engine, arriving at Puget Sound Navy Yard on 10 August. On 17 August, due to the end of the war, the Bureau of Ships decided not to repair the damage. The destroyer was decommissioned on 16 November 1945 and struck from the Navy list on 28 November. Later sold to the National Metal and Steel Corporation, Terminal Island, Los Angeles, for scrapping, her hulk was removed on 28 September 1947. Shubrick received four battle stars for her World War II service.
