The Panthers have the fifth-most Atlantic University Sport conference Championships, their last being the 2002–03 season. The AUS conference is a competitive Canadian league that has produced Canadian national champions, a Canadian Olympics player, several NBA draftees, and one NBA player.
David "Hermie" MacNeill - on the Saint Dunstan's University basketball team in 1967–68. Following his first year, MacNeill jointed the university's athletic staff as an athletic trainer. Through 2013 MacNeill spent every year involved in different positions in Prince Edward Island athletics and spent 12 years coaching the UPEI Women's Varsity Basketball Team. MacNeill earned many distinctions and honours as the UPEI Women's Coach with the highest distinction in taking the women's team to the U Sports championship game in 1989, winning the Silver Medal after losing to the undefeated University of Calgary team. He was five time Atlantic University Sport Coach of the Year.
Women's Basketball
The women's team have the fourth-most Atlantic Conference Championships, with their most recent for the 2019–20 season. The 2019–20 team also won the bronze medal at the 2020 U Sports Women's Basketball Championship.
Panthers Hockey
Men's Hockey
The Panthers are tied with the Mount Allison Mounties for the sixth-most Atlantic Conference Championships, their last being the 1990–91 season. The Panthers have never won the U Sports University Cup with only one appearance in the final in 1965 as their previous incarnation; the St. Dunstan's Saints. UPEI was the host venue for the championship once in 1970. Joel Ward of the NHL's San Jose Sharks played four seasons with the UPEI Panthers men's ice hockey team.
Women's Hockey
The women's team won their first Atlantic Conference Championship for the 2011-12 season.
Women's Rugby
Since rugby became a fully sanctioned Atlantic University Sport in 2002, the Panthers have finished runner up three times to the ever-dominant St. Francis Xavier X-Women.
Panthers Soccer
Men's Soccer
The men's team have the sixth-most Atlantic Conference Championships, their last title being in 2002. The men have never reached the U Sports Men's Soccer Championship final. UPEI was the host venue for the championship in 2005 and 2014. UPEI Men's Soccer made history in 2014 as the first Panther soccer team to medal at the U Sports Men's soccer Championship. The Panthers won bronze at home defeating the Canada West Champions, University of Saskatchewan Huskies in the quarter finals, before defeating the Quebec Champions, UQAM Citadens, in the Bronze medal game.
