UBQLN1
Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.
Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimer's disease. Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.Similarity to Other Proteins
Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.Interactions
UBQLN1 has been shown to interact with
