The section between the Oklahoma–Texas state line and Waco is mostly co-located with I-35 and the I-35E branch through Dallas, and where it is co-located, it is not signed. The two stretches in Texas that are not co-located are a stretch wholly within the city ofDenton and a longer stretch from near Red Oak, to Hillsboro, the reason being that US 77 is a separate road between the two, serving the town of Waxahachie. As of 2004, US 77 Alternate has a northern terminus in Hallettsville, Texas. It rejoins US 77 at Refugio, Texas. While the main line of US 77 passes through Victoria, Alternate US 77 veers to the west to serve Yoakum and Cuero. The southern end extends from I-37 near Corpus Christi to Harlingen, where it merges with US 83 and runs through the cities of Harlingen, San Benito and Brownsville to its southern terminus at the United States/Mexico border. A section of US 77 located in the Giddings, Texas area is known as the Martin Luther King Jr. Memorial Highway. Another section of US 77, from I-37 to SH 44 in Nueces County, was redesignated I-69/US 77 in 2011. As of 2017, US 77 is being co-signed with I-35E as part of the reconstruction co-signed between Denton and I-635.
Oklahoma
In Oklahoma, US 77 runs north–south, paralleling I-35, connecting Texas to Kansas and running for through the central part of the state. It passes through many major cities, including Ardmore, Oklahoma City and Norman, Guthrie, and Ponca City. It has a freeway section, the Broadway Extension, connecting Oklahoma City to its northern suburb Edmond, in addition to sections that are co-flagged with I-35 and I-235.
Kansas
US 77 runs for in Kansas. Between the US 40 junction and the Cowley County line is designated as a Blue Star Memorial Highway. In Cowley County, it is the Robert B. Docking Memorial Highway. Near Arkansas City it is the Walnut Valley Greenway. From Nebraska to US 24 and from K-15 to Arkansas City, it is part of the National Highway System.
Nebraska
In Nebraska, US 77 is a major north–south artery connecting the capital city of Lincoln with outlying areas to the north and south. The highway is designated as the Homestead Expressway from Beatrice to I-80 at Lincoln. In Lincoln, US 77 becomes a full controlled-access expressway before it overlaps with I-80 for about. North of I-80, US 77 continues as an expressway to Wahoo, where it becomes a two-lane undivided road. It remains a two-lane highway except for two sections near Fremont, which are four-lane divided highways. The expressway north of Fremont is shared with US 275 and Nebraska Highway 91. US 275 and NE 91 separate from US 77 just south of Winslow, and US 77 continues north as a two-lane highway until it meets US 75 at Winnebago. The two highways run together to the junction of I=129 and US 20 at Dakota City, where US 75 breaks off and US 77 continues northward as a divided highway through South Sioux City before exiting the state via the Siouxland Veterans Memorial Bridge.
Iowa
US 77 barely enters Iowa. After crossing the Missouri River via the Veteran's Bridge at Sioux City, the highway ends at a diamond interchange with I-29. Its total length in Iowa is slightly more than.
